One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2025-01-01 DOI:10.1016/j.fitote.2024.106339

Hong Zhang , Zhuoda Zhou , Minghua Yang , Shengyu Li , Xia Liu , Lu Jin , Qiyang Shou , Huiying Fu

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Abstract

One new polyketide asperfuranone D (1), four new sesquiterpenes derivatives aspergillone C-F (2–5) and three known compounds (6–8) were successfully isolated from Aspergillus nidulans LZ8, a fungicolous fungi from the macrofungal Ganoderma lingzhi. The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.7 cells. The results revealed that compound 5 showed moderate nitric oxide (NO) inhibitory activity with the IC₅₀ value of 13.19 ± 1.05 μM, while the IC₅₀ value of the positive control L-NMMA was 41.88 ± 0.91 μM.

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灵芝属真菌nidulaspergillus nidulans LZ8 1个新聚酮和4个新倍半萜衍生物。

从灵芝大真菌中分离得到1个新的聚酮阿斯曲霉酮D(1)、4个新的倍半萜衍生物曲霉酮C-F（2-5）和3个已知化合物（6-8）。这些化合物的结构通过广泛的光谱分析，包括紫外-可见光谱（UV）、质谱（MS）、核磁共振（NMR）和电子圆二色性（ECD）计算得到了阐明。此外，利用lps诱导的RAW 264.7细胞对新化合物的抗炎活性进行了评价。结果表明，化合物5具有中等的一氧化氮抑制活性，IC50值为13.19 ± 1.05 μM，阳性对照L-NMMA的IC50值为41.88 ± 0.91 μM。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.

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