Brain-derived neurotrophic factor as a promising neuromarker which could predict psychomotor developmental impairment in children with unrepaired congenital heart defects

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY International Journal of Developmental Neuroscience Pub Date : 2024-12-10 DOI:10.1002/jdn.10400

Lacramioara Eliza Chiperi, Asmaa Carla Hagau, Cristina Tecar, Adina Hutanu, Iolanda Muntean

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Abstract

Introduction

The aim of the study was to assess the predicting value of neuromarkers for psychomotor performances of congenital heart defect (CHD) patients before surgery, as until now the researchers only evaluated neuromarkers after the surgical treatment of the CHD.

Methods

This cross-sectional study included children with CHD who did not receive treatment (interventional or cardiac surgery). Psychomotor development was evaluated using the Denver II Screening Test. Blood samples were collected for neuromarkers analysis: neuron-specific enolase (NSE), protein S100 (pS100), brain-derived neurotrophic factor (BDNF), and glial fibrillary acidic protein (GFAP).

Results

We enrolled 77 children. Patients with CHD experienced more frequent developmental delays compared to healthy children (12–34% in the non-cyanotic group and 26–74% in the cyanotic group). The association between type of CHD and psychomotor impairment was statistically significant (p < 0.0001, RR = 2.604, CI = 2.07–3.26). Neuromarkers value was compared between cyanotic and non-cyanotic groups: NSE and BDNF values were higher in the cyanotic group, respectively, pS100 and GFAP had slightly higher values in the non-cyanotic group. A correlation coefficient of 0.35 (p = 0.023) was obtained between psychomotor development and BDNF level. An AUC of 0.72 was obtained for psychomotor development and BDNF in ROC analysis with the cut-off value of 5895 pg/ml.

Conclusion

BDNF is showing moderate discriminative ability in predicting psychomotor development outcomes in pediatric patients with CHD.

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脑源性神经营养因子作为预测未修复先天性心脏病患儿精神运动发育障碍的一种有前景的神经标志物。

导论：本研究的目的是评估神经标志物对先天性心脏缺陷（CHD）患者术前精神运动表现的预测价值，因为到目前为止，研究人员只评估了CHD手术治疗后的神经标志物。方法：本横断面研究纳入未接受治疗（介入性或心脏手术）的冠心病患儿。使用丹佛II筛选测试评估精神运动发展。采集血样进行神经标志物分析：神经元特异性烯醇化酶（NSE）、蛋白S100 （pS100）、脑源性神经营养因子（BDNF）、胶质原纤维酸性蛋白（GFAP）。结果：我们招募了77名儿童。与健康儿童相比，冠心病患者经历更频繁的发育迟缓（非紫绀组为12-34%，紫绀组为26-74%）。结论：BDNF在预测小儿冠心病患者精神运动发育结局方面具有中等判别能力。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.