Breaking boundaries: A systematic review of the application of non-invasive brain stimulation symptoms and sleep parameters in people with ADHD.

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY International Journal of Developmental Neuroscience Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI:10.1002/jdn.10401

Renato Mendes Dos Santos, Victor Marinho, Sabrina Nayara de Araújo Val, Ariel Soares Teles, Daniel Lima Sousa, Victor Hugo do Vale Bastos, Leonardo Peres de Souza, Angelina Ketllen Cachoeira de Sousa, Gabryella Stefane Firmino de Moraes, Silmar Teixeira

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Abstract

Background: Studies of non-invasive treatments such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) can contribute in an alternative way to the symptoms treatment and changes in sleep patterns in attention deficit hyperactivity disorder (ADHD), due to some scientific evidence of action on cognition and clinical characteristics.

Aim: The aim of this systematic review was to evaluate studies of non-invasive brain stimulation using rTMS and tDCS on symptoms and sleep parameters in people with ADHD, in order to synthesize the main findings on intervention effects.

Methodology: A systematic review was carried out using the PRISMA protocol in the PubMed/Medline, Embase, PsycInfo, CINAHL, PEDro and Central-Cochrane library databases were initially carried out on 14 March 2024 and repeated until September 2024. Randomized clinical trials evaluating the effect of rTMS and tDCS on symptoms and changes in sleep pattern in people with ADHD were included. Primary outcomes were total severity of ADHD symptoms and sleep quality assessed by questionnaires and instrument measures.

Results: The review evidenced only positive findings in five studies for tDCS in some cognitive functions, ADHD symptoms and improvement in sleep parameters, being results with reduced efficacy due to the high heterogeneity in the experimental protocols.

Conclusion: The findings show limited evidence; however, it is suggested that the combined use of non-invasive stimulation with other approaches, such as cognitive training, may improve the intervention effect. It is also important to consider limitations such as heterogeneity in clinical protocols, selection of participants with ADHD, including dosage and frequency. These factors should be explored in future research to optimize the application of these therapies.

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突破界限：对非侵入性脑刺激症状和睡眠参数在ADHD患者中的应用的系统回顾。

背景：重复性经颅磁刺激（rTMS）和经颅直流电刺激（tDCS）等非侵入性治疗方法的研究可以为注意缺陷多动障碍（ADHD）的症状治疗和睡眠模式的改变做出贡献，因为一些科学证据表明它们对认知和临床特征有作用。目的：本系统综述的目的是评价采用rTMS和tDCS的无创脑刺激对ADHD患者症状和睡眠参数的影响，以综合干预效果的主要研究结果。方法：采用PRISMA协议对PubMed/Medline、Embase、PsycInfo、CINAHL、PEDro和Central-Cochrane图书馆数据库进行系统评价，最初于2024年3月14日进行，并重复至2024年9月。包括评估rTMS和tDCS对ADHD患者症状和睡眠模式改变影响的随机临床试验。主要结果是ADHD症状的总严重程度和通过问卷调查和仪器测量评估的睡眠质量。结果：本综述仅证实了5项tDCS在某些认知功能、ADHD症状和睡眠参数改善方面的阳性结果，由于实验方案的高度异质性，这些结果的有效性降低。结论：研究结果证据有限；然而，建议将非侵入性刺激与其他方法（如认知训练）联合使用，可能会提高干预效果。同样重要的是要考虑局限性，如临床方案的异质性，ADHD患者的选择，包括剂量和频率。这些因素应在未来的研究中加以探讨，以优化这些疗法的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.