Establishment of epidemiological cut-off values of etimicin: a new fourth-generation aminoglycoside, against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus.

IF 3.9 2区医学 Q1 INFECTIOUS DISEASES Journal of Antimicrobial Chemotherapy Pub Date : 2025-02-03 DOI:10.1093/jac/dkae414

Ge Zhang, Zhengyu Luo, Qiwen Yang, Wei Kang, Jingjia Zhang, Jin Li, Tong Wang, Jie Lin, Yunsong Yu, Chuyue Zhuo, Chao Zhuo, Qihui Wang, Yunzhuo Chu, Zhongju Chen, Ziyong Sun, Dan Guo, Li Zhang, Yingchun Xu

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Abstract

Objective: To determine the epidemiological cut-off (ECOFF) values of etimicin against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus.

Methods: We selected 1500 isolates from five hospitals throughout five cities in China spanning from January 2018 to December 2021 in the study. Minimal inhibit concentrations (MICs) of etimicin were determined using the broth microdilution method. ECOFFs of etimicin against six species were calculated using ECOFFinder software and visual estimation following EUCAST principles.

Results: MICs of etimicin were distributed from 0.064 to >128 mg/L for S. aureus, from 0.125 to >128 mg/L for P. aeruginosa, from 0.25 to >128 mg/L for K. pneumoniae, P. mirabilis and A. baumannii, and from 0.5 to >128 mg/L for E. coli. The MIC ECOFF of etimicin was 2 mg/L for K. pneumoniae, 8 mg/L for E. coli and P. mirabilis, 16 mg/L for P. aeruginosa and A. baumannii, and the tentative ECOFF (TECOFF) of etimicin was 2 mg/L for S. aureus.

Conclusions: (T)ECOFFs of etimicin against E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa, A. baumannii and S. aureus were determined, which will be helpful to differentiate wild-type strains.

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第四代氨基糖苷依替米星抗大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌流行病学临界值的建立

目的：测定依替米星对大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌的流行病学截止值。方法：从2018年1月至2021年12月，从中国5个城市的5家医院中选取1500株分离株进行研究。采用肉汤微量稀释法测定依替米星的最低抑菌浓度。采用ECOFFinder软件计算依替米星对6种物种的ecoff，并按照EUCAST原则进行目视估计。结果：依替米星对金黄色葡萄球菌的mic值为0.064 ~ >28mg /L，铜绿假单胞菌的mic值为0.125 ~ >28mg /L，肺炎克雷伯菌、奇假单胞菌和鲍曼不动杆菌的mic值为0.25 ~ >28mg /L，大肠杆菌的mic值为0.5 ~ >28mg /L。依替米星对肺炎克雷伯菌的MIC ECOFF为2 mg/L，对大肠杆菌和神奇假单胞菌的MIC ECOFF为8 mg/L，对铜绿假单胞菌和鲍曼假单胞菌的MIC ECOFF为16 mg/L，对金黄色葡萄球菌的ECOFF （TECOFF）为2 mg/L。结论：(1)测定了依替米星对大肠杆菌、肺炎克雷伯菌、神奇假单胞菌、铜绿假单胞菌、鲍曼假单胞菌和金黄色葡萄球菌的ecoff，有助于野生型菌株的鉴别。

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来源期刊

Journal of Antimicrobial Chemotherapy 医学-传染病学

CiteScore

9.20

自引率

5.80%

发文量

423

审稿时长

2-4 weeks

期刊介绍： The Journal publishes articles that further knowledge and advance the science and application of antimicrobial chemotherapy with antibiotics and antifungal, antiviral and antiprotozoal agents. The Journal publishes primarily in human medicine, and articles in veterinary medicine likely to have an impact on global health.