Correction to “Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005”

IF 6.8 1区医学 Q1 CHEMISTRY, MEDICINAL Journal of Medicinal Chemistry Pub Date : 2024-12-12 DOI:10.1021/acs.jmedchem.4c02898

Patrick Papa, Brandon Whitefield, Deborah S. Mortensen, Dan Cashion, Dehua Huang, Eduardo Torres, Jason Parnes, John Sapienza, Joshua Hansen, Matthew Correa, Mercedes Delgado, Roy Harris, Sayee Hegde, Stephen Norris, Sogole Bahmanyar, Veronique Plantevin-Krenitsky, Zheng Liu, Katerina Leftheris, Ashutosh Kulkarni, Brydon Bennett, Eun Mi Hur, Garth Ringheim, Godrej Khambatta, Henry Chan, Jeffrey Muir, Kate Blease, Kelven Burnett, Laurie LeBrun, Lisa Morrison, Maria Celeridad, Roli Khattri, Brian E. Cathers

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Abstract

In Figure 3 and the related text, Asp508 was incorrectly labeled as Asp409 due to typographical error in figure preparation. The corrected figure and updated line of text are as follow: Figure 3. Docking model of 3 bound in the ATP pocket of PKC-θ (PDB ID 1XJD used for docking studies). Page 11889: “The basic piperidine amine forms two salt-bridges with side-chain carboxylates of Asp465 and catalytic residue Asp522 and forms a third hydrogen bond to the backbone carbonyl of Asp508.” This article has not yet been cited by other publications.

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对“发现选择性蛋白激酶C-θ激酶抑制剂CC-90005”的更正

在图3和相关文本中，由于图准备中的印刷错误，Asp508被错误地标记为Asp409。更正后的图和更新后的文本行如下：图3。PKC-θ ATP口袋中3结合的对接模型（PDB ID 1XJD用于对接研究）。11889页：“碱性哌啶胺与侧链羧酸Asp465和催化残基Asp522形成两个盐桥，并与Asp508的主羰基形成第三个氢键。”这篇文章尚未被其他出版物引用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medicinal Chemistry 医学-医药化学

CiteScore

4.00

自引率

11.00%

发文量

804

审稿时长

1.9 months

期刊介绍： The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.