Toxicokinetics of aluminium - novel insights in an old adjuvant

IF 1 Q4 ALLERGY Allergo Journal Pub Date : 2024-12-12 DOI:10.1007/s15007-024-6395-x

Karin Weisser

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Abstract

Purpose: In 2015, an interdisciplinary project was started to fill the gap of knowledge on the toxicokinetics of aluminium (Al) after exposure from adjuvanted products for subcutaneous immunotherapy (SCIT).

Methods: Two complementary initiatives of the project are explained. The results of two studies are reviewed and put in connection with the overarching goal. An estimate is given which steps have been reached and which are still needed.

Results: Recent in vivo data provided evidence of systemically available Al from SCIT products in rats (Weisser et al. 2020 [1]). The data are highly valuable for further development of the physiology-based toxicokinetic (PBTK) model for Al exposure which has been established in parallel (Hethey et al. 2021 [2]).

Conclusion: The Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted.

Cite this as: Weisser K. Toxicokinetics of aluminium - novel insights in an old adjuvant. Allergo J Int 2024;33:304-8

https://doi.org/10.1007/s40629-024-00288-7

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铝的毒性动力学——一种旧佐剂的新见解

目的：2015年启动了一项跨学科项目，以填补关于皮下免疫治疗（SCIT）佐剂产品暴露后铝（Al）毒性动力学的知识空白。方法：对项目的两个互补举措进行了解释。审查了两项研究的结果，并将其与总体目标联系起来。报告估计了哪些步骤已经完成，哪些步骤仍然需要完成。结果：最近的体内数据提供了证据，证明SCIT产品在大鼠体内可以全身获得Al （Weisser et Al . 2020 b[1]）。这些数据对于进一步发展基于生理的铝暴露毒性动力学（PBTK）模型具有很高的价值，该模型已并行建立（Hethey等人，2021[2]）。结论：Hethey模型是预测人体各种来源铝暴露的重要一步。为了用于科学技术产品铝暴露的风险评估，进一步扩展模型是必要的。引用这是：威瑟K.铝的毒性动力学——在一种旧佐剂中的新见解。[J] .中国科学：自然科学学报（英文版）；2009;33:391 - 391

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Allergo Journal ALLERGY-

自引率

18.20%

发文量

175

期刊介绍： The Allergo Journal publishes original articles, reviews and case reports, guidelines and position papers in German and English. The topics concern allergological and immunological clinical pictures, current developments in diagnosis and therapy, research work concerning antigens and allergens and aspects related to occupational and environmental medicine. The quality of the contributions is guaranteed by an international board of editors; all contributions will be reviewed by at least two independent peers.

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