A Rare Case of NK Large Granular Lymphocytic Proliferative Disorder.

IF 0.7 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-12-01 DOI:10.7754/Clin.Lab.2024.240712
Lei Shang, Qi Hao, Cunwei Liu, Xuekai Liu
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引用次数: 0

Abstract

Background: Chronic NK-cell lymphoproliferative disease (CLPD-NK) is a very rare lymphoproliferative disorder in which patients often have an elevated lymphocyte population without clinical symptoms.

Methods: In this particular case, a middle-aged woman presented with a consistent elevation in her lymphocyte proportion over a span of four consecutive years during physical examinations, without manifesting any other notable clinical symptoms. The underlying cause of this phenomenon was ultimately identified through a comprehensive evaluation that encompassed peripheral blood cell morphology analysis, lymphocyte subset profiling, and peripheral blood immunophenotyping. These diagnostic tools collectively provided crucial insights into the nature of the disease.

Results: The patient was finally diagnosed with CLPD-NK. As part of her management plan, the patient was advised to undergo regular annual physical examinations to monitor the progression of the disease and any potential changes in her health status.

Conclusions: CLPD-NK is a chronic progressive lymphoproliferative disease, which can be followed up regularly if there are no clinical symptoms. Severe reductions in neutrophils, red blood cells, and platelets or other complications may require chemotherapy or bone marrow transplantation.

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罕见的NK大颗粒淋巴细胞增生性疾病1例。
背景:慢性nk细胞性淋巴细胞增生性疾病(CLPD-NK)是一种非常罕见的淋巴细胞增生性疾病,患者通常有淋巴细胞群升高而无临床症状。方法:在这个特殊的病例中,一位中年妇女在连续四年的体检中出现了淋巴细胞比例的持续升高,没有表现出任何其他明显的临床症状。这种现象的根本原因最终通过包括外周血形态分析、淋巴细胞亚群分析和外周血免疫表型的综合评估确定。这些诊断工具共同提供了对疾病性质的重要见解。结果:患者最终确诊为CLPD-NK。作为其管理计划的一部分,建议患者每年定期进行体检,以监测疾病的进展和其健康状况的任何潜在变化。结论:CLPD-NK是一种慢性进行性淋巴细胞增生性疾病,如无临床症状,可定期随访。中性粒细胞、红细胞和血小板的严重减少或其他并发症可能需要化疗或骨髓移植。
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来源期刊
Clinical laboratory
Clinical laboratory 医学-医学实验技术
CiteScore
1.50
自引率
0.00%
发文量
494
审稿时长
3 months
期刊介绍: Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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