Distribution and Drug Resistance of Pathogens of Catheter-Related Blood Stream Infection in a Hospital from 2017 to 2021.

Abstract

Background: We analyzed the clinical distribution and the antibiotic susceptibility of pathogens for catheter-related blood stream infection (CRBSI) in the hospital retrospectively.

Methods: The clinical information and pathogens associated with CRBSI were collected from the Microbiology Laboratory of the hospital retrospectively from January 2017 to December 2021. Identification and the antibiotic susceptibility test (AST) were carried out with VITEK-2 Compact. The data were analyzed by WHONET 5.6.

Results: A total of 138 isolates (6.4%) associated with CRBSI were found during the 5-year period. Among the pathogens of CRBSI, 89 (64.5%) isolates were coagulase-negative Staphylococcus, 6 (4.3%) were strains of Enterococcus, and 4 (2.9%) were strains of Staphylococcus aureus. Staphylococci and Streptococci were all sensitive to Linezolid, Vancomycin, Quinuprine/Dafuprine, and Tigecycline. There were 39 (28.3%) Gram-negative bacilli isolates, including 17 strains of Klebsiella pneumoniae (12.3%), 6 (4.3%) strains of Acinetobacter baumannii, and 6 (4.3%) strains of Burkholderia cepacia. The drug resistance rates of Gram-negative bacilli to most drugs were higher than 50%. The main departments where CRBSI pathogens were isolated were Peritoneal Tumor Surgery (86, 62.3%), ICU (20, 14.5%), Emergency Department (6, 4.3%), and Respiratory Department (6, 4.3%).

Conclusions: With the emergence of multidrug-resistant (MDR) bacteria, more attention should be paid to the prevention and control of nosocomial infections. At the same time, the use and management of antibiotics should be standardized, and monitoring of multidrug-resistant bacteria should be strengthened in hospitals.