Identification of Chronic Hypertension in Pregnancy in Three Administrative Data Sources Among Medicaid-Funded Births in California.

IF 2.4 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pharmacoepidemiology and Drug Safety Pub Date : 2024-12-01 DOI:10.1002/pds.70059
Erin Delker, Rebecca J Baer, Christina D Chambers, Gretchen Bandoli
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Abstract

Purpose: Administrative data sources are used to describe the epidemiology of chronic hypertension in pregnancy and its consequences. Differences in identification across sources may affect research estimates. We compared identification of chronic hypertension in birth certificate records, hospital discharge records, and Medi-Cal claims in the same individuals.

Methods: We used data from 820 140 2016-2020 California Medi-Cal covered births. We identified chronic hypertension on birth certificates using the prepregnancy hypertension check box and in hospital discharge records and Medi-Cal claims using ICD codes. We compared the prevalence of chronic hypertension and identified predictors of agreement. We also compared absolute and relative estimates of racial/ethnic disparities in chronic hypertension and associations with neonatal outcomes.

Results: The prevalence of chronic hypertension was 0.7% in birth records, 2.1% in hospital discharge records, and 3.9% in Medi-Cal claims. There was low to fair agreement between birth certificate records and hospitalization records (kappa = 0.36) and Medi-Cal claims (kappa = 0.25). Characteristics associated with the worst agreement were eligibility for Women Infant and Children benefits, US-born, and normal body mass index. Estimates of the relative risk for racial/ethnic disparities and associations with preterm birth and SGA age at delivery were similar across sources. Estimates of risk differences were larger in hospitalization and Medi-Cal claims data.

Conclusions: Reliance on birth certificate data may contribute to underestimated prevalence estimates and biased causal estimates. Epidemiologic research and public health surveillance of chronic hypertension and its consequences should incorporate data from multiple data sources to improve validity of estimates.

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在加州医疗补助资助出生的三个行政数据来源中确定妊娠期慢性高血压。
目的:利用行政资料来源描述妊娠期慢性高血压的流行病学及其后果。不同来源的识别差异可能会影响研究估计。我们比较了同一个体的出生证明记录、出院记录和Medi-Cal索赔中慢性高血压的鉴定。方法:我们使用2016-2020年加州医疗保险覆盖的820 - 140名新生儿的数据。我们在出生证明上使用孕前高血压复选框确定慢性高血压,在出院记录和Medi-Cal索赔中使用ICD代码确定慢性高血压。我们比较了慢性高血压的患病率,并确定了一致的预测因素。我们还比较了慢性高血压的种族/民族差异及其与新生儿结局的关系的绝对和相对估计。结果:慢性高血压的患病率在出生记录中为0.7%,出院记录中为2.1%,在Medi-Cal索赔中为3.9%。出生证明记录和住院记录(kappa = 0.36)与Medi-Cal索赔(kappa = 0.25)之间的一致性低至公平。与最差协议相关的特征是妇女、婴儿和儿童福利资格、美国出生和正常体重指数。对种族/民族差异的相对风险以及与早产和分娩时SGA年龄的关联的估计在各来源中相似。住院治疗和Medi-Cal索赔数据的风险差异估计更大。结论:对出生证明数据的依赖可能导致低估了患病率估计和有偏差的因果估计。慢性高血压及其后果的流行病学研究和公共卫生监测应纳入来自多个数据来源的数据,以提高估计的有效性。
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来源期刊
CiteScore
4.80
自引率
7.70%
发文量
173
审稿时长
3 months
期刊介绍: The aim of Pharmacoepidemiology and Drug Safety is to provide an international forum for the communication and evaluation of data, methods and opinion in the discipline of pharmacoepidemiology. The Journal publishes peer-reviewed reports of original research, invited reviews and a variety of guest editorials and commentaries embracing scientific, medical, statistical, legal and economic aspects of pharmacoepidemiology and post-marketing surveillance of drug safety. Appropriate material in these categories may also be considered for publication as a Brief Report. Particular areas of interest include: design, analysis, results, and interpretation of studies looking at the benefit or safety of specific pharmaceuticals, biologics, or medical devices, including studies in pharmacovigilance, postmarketing surveillance, pharmacoeconomics, patient safety, molecular pharmacoepidemiology, or any other study within the broad field of pharmacoepidemiology; comparative effectiveness research relating to pharmaceuticals, biologics, and medical devices. Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition, as these methods are truly used in the real world; methodologic contributions of relevance to pharmacoepidemiology, whether original contributions, reviews of existing methods, or tutorials for how to apply the methods of pharmacoepidemiology; assessments of harm versus benefit in drug therapy; patterns of drug utilization; relationships between pharmacoepidemiology and the formulation and interpretation of regulatory guidelines; evaluations of risk management plans and programmes relating to pharmaceuticals, biologics and medical devices.
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