Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats.

Acta cirurgica brasileira Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI:10.1590/acb399624

Rosana Soares Araújo Doci, Filipe Feitosa de Carvalho, Rodrigo César Gomes, Reinaldo José Gianini, Camilla Fanelli, Irene de Lourdes Noronha, Nelson Brancaccio Dos Santos, Moema de Alencar Hausen, Daniel Komatsu, Priscila Randazzo-Moura

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Abstract

Purpose: The surgical glue is widely used in closing cutaneous surgical wounds. Corticosteroids are indicated for their anti-inflammatory and immunomodulatory properties. The present work evaluated the pharmacological effects of triamcinolone (AT) incorporated into surgical glue (C) on the initial phase of the wound healing process in Wistar rats.

Methods: Through in-vivo studies, the effects of the healing process, C or C+AT in the same rat were evaluated for seven and 14 days post-surgery.

Results: The C+AT association did not change the physicochemical properties of the polymer. This association in wound healing confirmed the anti-inflammatory and immunomodulatory effects of the corticosteroid, with less neovascularization and fibrosis, in addition to the remodeling of the extracellular matrix carried out by the balance of myofibroblasts and less dense collagen fibers, culminating in tissue regeneration and possible reduction of side effects.

Conclusion: This association is a powerful and innovative pharmacological tool, promising in translational medicine.

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