Epidemiology of Multidrug-Resistant Salmonella Typhi and Paratyphi Isolated From Stool Culture.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI:10.1155/jotm/3480080
Tito Aloys Ndima Etouke, Georges Ful Kuh, Boris Emmanuel Djoumsie Gomseu, Vanessa Linda Nzesseu, Jean-De-Dieu Tamokou, Jean Paul Dzoyem
{"title":"Epidemiology of Multidrug-Resistant <i>Salmonella</i> Typhi and Paratyphi Isolated From Stool Culture.","authors":"Tito Aloys Ndima Etouke, Georges Ful Kuh, Boris Emmanuel Djoumsie Gomseu, Vanessa Linda Nzesseu, Jean-De-Dieu Tamokou, Jean Paul Dzoyem","doi":"10.1155/jotm/3480080","DOIUrl":null,"url":null,"abstract":"<p><p>Enteric fever is a significant health problem in developing countries caused by <i>Salmonella enterica</i> serovars Typhi and Paratyphi. Unfortunately, the burden of the disease remains high not only because of the complications related to the disease but also, especially, because of the spread of the strains of <i>Salmonella</i> resistant to antibiotics. The aim of the present study was to evaluate the antibiotic resistance patterns of <i>Salmonella</i> Typhi and Paratyphi clinical isolates as well as the risk factors associated with infection. This cross-sectional study was conducted from June 2020 to September 2021. One thousand and seventy-six patients in the age range (1- ≥ 50 years) were recruited including 423 (39.31%) infected with <i>S.</i> Typhi, 115 (10.68%) infected with <i>S.</i> Paratyphi, and 538 (50%) noninfected after obtaining their informed consent using a face-to-face interview and questionnaire. The stool samples were collected in clean and sterile boxes reserved for this purpose and were cultured. Demographic parameters such as sex, age, occupation, water source, level of education, as well as clinical signs and symptoms were obtained. The resistance profile determination was carried out by the disk diffusion method. A multivariate logistic regression analysis was performed to identify factors associated with infection. Results of multivariate logistic regression analysis showed positive and significant associations (OR > 1; <i>p</i> < 0.05) between enteric fever and women among the age groups: 1-10 years, 11-20 years, and 21-30 years. These positive associations were also noted in patients who ate shellfish, salads, fruits, and vegetables; in patients who consumed ice cubes; as well as those who consumed food and drinks offered by ambulant merchants. This indicated that they are more likely to be infected by <i>S. enterica</i> than others. The level of multidrug-resistant (MDR) <i>S. enterica</i> to first-line antimicrobial agents ampicillin, chloramphenicol, and co-trimoxazole was high and selectively distributed according to age groups, marital status, profession, level of education, source of water, and lifestyle. The results highlighted the emergence of MDR <i>S. enterica</i> isolated in the study population, demonstrating resistance to first-line drugs, fluoroquinolones, and third-generation cephalosporins. Further studies with large-scale samples are needed to validate the present results and to monitor MDR <i>S.</i> Typhi and <i>S.</i> Paratyphi serovars in other parts of Cameroon.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2024 ","pages":"3480080"},"PeriodicalIF":2.1000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637623/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tropical Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/jotm/3480080","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Enteric fever is a significant health problem in developing countries caused by Salmonella enterica serovars Typhi and Paratyphi. Unfortunately, the burden of the disease remains high not only because of the complications related to the disease but also, especially, because of the spread of the strains of Salmonella resistant to antibiotics. The aim of the present study was to evaluate the antibiotic resistance patterns of Salmonella Typhi and Paratyphi clinical isolates as well as the risk factors associated with infection. This cross-sectional study was conducted from June 2020 to September 2021. One thousand and seventy-six patients in the age range (1- ≥ 50 years) were recruited including 423 (39.31%) infected with S. Typhi, 115 (10.68%) infected with S. Paratyphi, and 538 (50%) noninfected after obtaining their informed consent using a face-to-face interview and questionnaire. The stool samples were collected in clean and sterile boxes reserved for this purpose and were cultured. Demographic parameters such as sex, age, occupation, water source, level of education, as well as clinical signs and symptoms were obtained. The resistance profile determination was carried out by the disk diffusion method. A multivariate logistic regression analysis was performed to identify factors associated with infection. Results of multivariate logistic regression analysis showed positive and significant associations (OR > 1; p < 0.05) between enteric fever and women among the age groups: 1-10 years, 11-20 years, and 21-30 years. These positive associations were also noted in patients who ate shellfish, salads, fruits, and vegetables; in patients who consumed ice cubes; as well as those who consumed food and drinks offered by ambulant merchants. This indicated that they are more likely to be infected by S. enterica than others. The level of multidrug-resistant (MDR) S. enterica to first-line antimicrobial agents ampicillin, chloramphenicol, and co-trimoxazole was high and selectively distributed according to age groups, marital status, profession, level of education, source of water, and lifestyle. The results highlighted the emergence of MDR S. enterica isolated in the study population, demonstrating resistance to first-line drugs, fluoroquinolones, and third-generation cephalosporins. Further studies with large-scale samples are needed to validate the present results and to monitor MDR S. Typhi and S. Paratyphi serovars in other parts of Cameroon.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
期刊最新文献
Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice. Epidemiology of Multidrug-Resistant Salmonella Typhi and Paratyphi Isolated From Stool Culture. Snakebite Envenomation From the Large Palearctic Viper, Macrovipera razii (Squamata: Serpentes; Viperidae), in Fars Province, Southern Iran. Determinants of Visceral Leishmaniasis in Addis Zemen Health Center, Northwest Ethiopia. Exploring the Antimalarial Potential of Gnetum gnemon Leaf Extract Against Plasmodium berghei in Mice.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1