Unlocking the therapeutic potential of WISP-1: A comprehensive exploration of its role in age-related musculoskeletal disorders

IF 4.7 2区医学 Q2 IMMUNOLOGY International immunopharmacology Pub Date : 2025-01-03 DOI:10.1016/j.intimp.2024.113791

Wenhao Lu , Wenjie Feng , Haozu zhen , Shide Jiang , Yusheng Li , Shuguang Liu , Qin Ru , Wenfeng Xiao

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Abstract

As the global population ages, the incidence of age-related musculoskeletal diseases continues to increase, driven by numerous complex and poorly understood factors. WNT-1 inducible secreted protein 1 (WISP-1), a secreted matrix protein, plays a critical role in the growth and development of the musculoskeletal system, including chondrogenesis, osteogenesis, and myogenesis. Numerous in vivo and in vitro studies have demonstrated that WISP-1 is significantly upregulated in age-related musculoskeletal conditions, such as osteoarthritis, osteoporosis, and sarcopenia, suggesting its involvement in the pathogenesis of these diseases. Regulating WISP-1 expression holds promise as a therapeutic strategy for improving musculoskeletal function, potentially offering new avenues for treating age-related musculoskeletal diseases in clinical practice. This review highlights the signaling pathways associated with WISP-1, its physiological roles within the musculoskeletal system, and its therapeutic potential in treating age-related musculoskeletal disorders.

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挖掘 WISP-1 的治疗潜力：全面探索其在与年龄相关的肌肉骨骼疾病中的作用。

随着全球人口老龄化，与年龄相关的肌肉骨骼疾病的发病率继续增加，这是由许多复杂且知之甚少的因素驱动的。WNT-1诱导分泌蛋白1 （WNT-1 inducible secreted protein 1, WISP-1）是一种分泌基质蛋白，在肌肉骨骼系统的生长发育中起关键作用，包括软骨形成、成骨和肌生成。大量体内和体外研究表明，WISP-1在与年龄相关的肌肉骨骼疾病（如骨关节炎、骨质疏松症和肌肉减少症）中显著上调，表明其参与了这些疾病的发病机制。调节WISP-1的表达有望成为改善肌肉骨骼功能的治疗策略，可能为临床实践中治疗与年龄相关的肌肉骨骼疾病提供新的途径。这篇综述强调了与WISP-1相关的信号通路，它在肌肉骨骼系统中的生理作用，以及它在治疗年龄相关肌肉骨骼疾病中的治疗潜力。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.