Age-Related Differences Between Juvenile and Adult Autoimmune Inflammatory Myopathies.

IF 2.4 4区 医学 Q2 RHEUMATOLOGY JCR: Journal of Clinical Rheumatology Pub Date : 2024-12-12 DOI:10.1097/RHU.0000000000002180
Melike Mehveş Kaplan, Zahide Ekici Tekin, Elif Çelikel, Vildan Güngörer, Cüneyt Karagöl, Nimet Öner, Merve Cansu Polat, Didem Öztürk, Emine Özçelik, Mehveş Işıklar Ekici, Pınar Akyüz Dağlı, Şükran Erten, Banu Çelikel Acar
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Abstract

Background: Clinical features and prognosis of autoimmune inflammatory myopathies (AIMs) can vary depending on the age of disease onset. The aim of this study was to compare the demographic characteristics, clinical features, laboratory findings, and long-term prognosis of juvenile and adult AIMs.

Methods: Patients diagnosed with AIM between 2009 and 2023 in the pediatric rheumatology and rheumatology departments of our hospital were included in this medical records review study. Demographic characteristics, clinical features, laboratory findings, treatments, and prognosis of juvenile and adult AIM patients were compared with statistical methods.

Results: Of the 94 patients diagnosed with AIM, 34 (36.2%) patients were juvenile and 60 (63.8%) patients were adult. At the time of diagnosis, while Gottron papules, dysphonia, and subcutaneous edema were more common in juvenile patients, fever was more common in adult patients (p = 0.003, p = 0.05, p = 0.005 p = 0.05, respectively). During follow-up, while calcinosis was more common in juvenile patients, lung involvement and malignancy were more common in adult patients (p = 0.022, p = 0.009, p = 0.006, respectively). The methylprednisolone pulse therapy requirement was significantly higher in juvenile patients (p = 0.0001). Clinically inactive disease was more common in juvenile patients (p = 0.01).

Conclusions: AIM with different onset ages is associated with distinct clinical manifestations and outcomes. The present study reported that in AIM patients, lung involvement and malignancy increase with age while clinically inactive disease decreases.

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青少年和成年自身免疫性炎症性肌病之间与年龄有关的差异
背景:自身免疫性炎症性肌病(AIMs)的临床特征和预后会因发病年龄而异。本研究旨在比较幼年和成年自身免疫性炎症性肌病的人口统计学特征、临床特征、实验室检查结果和长期预后:方法:将本院儿童风湿病科和风湿病科 2009 年至 2023 年期间确诊的 AIM 患者纳入病历回顾研究。用统计学方法比较了幼年和成年 AIM 患者的人口统计学特征、临床特征、实验室检查结果、治疗方法和预后:在 94 名确诊为 AIM 的患者中,34 名(36.2%)为青少年患者,60 名(63.8%)为成人患者。确诊时,幼年患者多见戈特龙丘疹、发音障碍和皮下水肿,而成年患者多见发热(分别为 p = 0.003、p = 0.05、p = 0.005、p = 0.05)。在随访期间,青少年患者更常见钙化,而成年患者更常见肺部受累和恶性肿瘤(分别为 p = 0.022、p = 0.009、p = 0.006)。青少年患者的甲基强的松龙脉冲疗法需求量明显更高(p = 0.0001)。临床上不活跃的疾病在青少年患者中更为常见(p = 0.01):结论:不同发病年龄的 AIM 具有不同的临床表现和预后。本研究报告显示,AIM 患者的肺部受累和恶性肿瘤随年龄增长而增加,而临床非活动性疾病则随年龄增长而减少。
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来源期刊
CiteScore
3.50
自引率
2.90%
发文量
228
审稿时长
4-8 weeks
期刊介绍: JCR: Journal of Clinical Rheumatology the peer-reviewed, bimonthly journal that rheumatologists asked for. Each issue contains practical information on patient care in a clinically oriented, easy-to-read format. Our commitment is to timely, relevant coverage of the topics and issues shaping current practice. We pack each issue with original articles, case reports, reviews, brief reports, expert commentary, letters to the editor, and more. This is where you''ll find the answers to tough patient management issues as well as the latest information about technological advances affecting your practice.
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