{"title":"Models of human hippocampal specialization: a look at the electrophysiological evidence.","authors":"Anne Freelin, Cody Wolfe, Bradley Lega","doi":"10.1016/j.tics.2024.11.009","DOIUrl":null,"url":null,"abstract":"<p><p>From an anatomical perspective, the concept that the anterior and posterior hippocampus fulfill distinct cognitive roles may seem unsurprising. When compared with the posterior hippocampus, the anterior region is proportionally larger, with visible expansion of the CA1 subfield and intimate continuity with adjacent medial temporal lobe (MTL) structures such as the uncus and amygdala. However, the functional relevance emerging from these anatomical differences remains to be established in humans. Drawing on both rodent and human data, several models of hippocampal longitudinal specialization have been proposed. For the brevity and clarity of this review, we focus on human electrophysiological evidence supporting and contravening these models with limited inclusion of noninvasive data. We then synthesize these data to propose a novel longitudinal model based on the amount of contextual information, drawing on previous conceptions described within the past decade.</p>","PeriodicalId":49417,"journal":{"name":"Trends in Cognitive Sciences","volume":" ","pages":""},"PeriodicalIF":16.7000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Cognitive Sciences","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1016/j.tics.2024.11.009","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
From an anatomical perspective, the concept that the anterior and posterior hippocampus fulfill distinct cognitive roles may seem unsurprising. When compared with the posterior hippocampus, the anterior region is proportionally larger, with visible expansion of the CA1 subfield and intimate continuity with adjacent medial temporal lobe (MTL) structures such as the uncus and amygdala. However, the functional relevance emerging from these anatomical differences remains to be established in humans. Drawing on both rodent and human data, several models of hippocampal longitudinal specialization have been proposed. For the brevity and clarity of this review, we focus on human electrophysiological evidence supporting and contravening these models with limited inclusion of noninvasive data. We then synthesize these data to propose a novel longitudinal model based on the amount of contextual information, drawing on previous conceptions described within the past decade.
期刊介绍:
Essential reading for those working directly in the cognitive sciences or in related specialist areas, Trends in Cognitive Sciences provides an instant overview of current thinking for scientists, students and teachers who want to keep up with the latest developments in the cognitive sciences. The journal brings together research in psychology, artificial intelligence, linguistics, philosophy, computer science and neuroscience. Trends in Cognitive Sciences provides a platform for the interaction of these disciplines and the evolution of cognitive science as an independent field of study.