A V Gavryushin, A A Veselkov, E A Khukhlaeva, A N Konovalov, A E Druy
{"title":"[Liquid biopsy in diagnosis of central nervous system tumors].","authors":"A V Gavryushin, A A Veselkov, E A Khukhlaeva, A N Konovalov, A E Druy","doi":"10.17116/neiro202488061110","DOIUrl":null,"url":null,"abstract":"<p><p>Tumor tissue samples are necessary for histological diagnosis. Biopsy is associated with certain difficulties, especially in neuro-oncology. An alternative approach (liquid biopsy) is currently being developed. The last one is based on analysis of biological fluids regarding DNA of tumors and other biomarkers. This less invasive diagnostic method may be valuable to overcome the disadvantages of traditional biopsy.</p><p><strong>Objective: </strong>To analyze available literature data on potential benefits and disadvantages of liquid biopsy.</p><p><strong>Material and methods: </strong>We reviewed the PubMed database throughout the last 18 years.</p><p><strong>Results: </strong>The main targets for liquid biopsy are circulating tumor cells, extracellular vesicles, free circulating DNA and tumor microRNA. Analysis of these biomarkers is perspective for diagnostics and assessment of diseases in neuro-oncology. However, this technique is still poorly understood and has limitations. Therefore, further research is required to explore its capabilities for wider use in clinical practice.</p><p><strong>Conclusion: </strong>Tissue and liquid biopsy can improve the accuracy of diagnosis, assessment of prognosis and effectiveness of treatment of CNS tumors.</p>","PeriodicalId":24032,"journal":{"name":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","volume":"88 6","pages":"110-117"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/neiro202488061110","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Tumor tissue samples are necessary for histological diagnosis. Biopsy is associated with certain difficulties, especially in neuro-oncology. An alternative approach (liquid biopsy) is currently being developed. The last one is based on analysis of biological fluids regarding DNA of tumors and other biomarkers. This less invasive diagnostic method may be valuable to overcome the disadvantages of traditional biopsy.
Objective: To analyze available literature data on potential benefits and disadvantages of liquid biopsy.
Material and methods: We reviewed the PubMed database throughout the last 18 years.
Results: The main targets for liquid biopsy are circulating tumor cells, extracellular vesicles, free circulating DNA and tumor microRNA. Analysis of these biomarkers is perspective for diagnostics and assessment of diseases in neuro-oncology. However, this technique is still poorly understood and has limitations. Therefore, further research is required to explore its capabilities for wider use in clinical practice.
Conclusion: Tissue and liquid biopsy can improve the accuracy of diagnosis, assessment of prognosis and effectiveness of treatment of CNS tumors.
组织学诊断需要肿瘤组织样本。活检存在一定的困难，尤其是在神经肿瘤学领域。目前正在开发一种替代方法（液体活检）。最后一种方法基于对生物液体中肿瘤 DNA 和其他生物标记物的分析。这种侵入性较小的诊断方法可能对克服传统活检的缺点很有价值：分析有关液体活检潜在利弊的现有文献数据：我们查阅了PubMed数据库过去18年的相关资料：液体活检的主要目标是循环肿瘤细胞、细胞外囊泡、游离循环 DNA 和肿瘤 microRNA。对这些生物标志物的分析是诊断和评估神经肿瘤学疾病的一个视角。然而，人们对这项技术的了解还很不够，而且它还存在局限性。因此，需要进一步开展研究，探索其在临床实践中广泛应用的能力：组织和液体活检可提高中枢神经系统肿瘤诊断的准确性、预后评估和治疗效果。
期刊介绍：
Scientific and practical peer-reviewed journal. This publication covers the theoretical, practical and organizational problems of modern neurosurgery, the latest advances in the treatment of various diseases of the central and peripheral nervous system. Founded in 1937. English version of the journal translates from Russian version since #1/2013.
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