LRP11-AS1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal Cancer via the miR-149-3p/CDK4 pathway.

IF 4.8 3区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Cancer gene therapy Pub Date : 2024-12-13 DOI:10.1038/s41417-024-00862-9
Zhongguang Wu, Mengqiu Yu, Yu Zeng, Yingfeng Huang, Weidong Zheng
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Abstract

Long noncoding RNAs (lncRNAs) are critical in tumorigenesis and show potential for tumor diagnosis and therapy. Enterotoxigenic Bacteroides fragilis (ETBF), known for producing enterotoxins, is implicated in human gut tumorigenesis, yet the underlying mechanisms are not fully elucidated. This study aims to clarify the molecular mechanisms by which lncRNAs contribute to ETBF-induced tumorigenesis, with a focus on LRP11-AS1's role in modulating ETBF's colorectal carcinogenesis. We found a marked increase in LRP11-AS1 expression in colorectal cancer (CRC) tissues compared to adjacent non-tumorous tissues. In vitro, CRC cells exposed to ETBF showed elevated LRP11-AS1 levels. Mechanistically, LRP11-AS1 was shown to enhance CDK4 expression by competitively binding to miR-149-3p. These results indicate that LRP11-AS1 may facilitate ETBF-related carcinogenesis in CRC and could serve as a therapeutic target and diagnostic biomarker for ETBF-associated CRC.

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LRP11-AS1通过miR-149-3p/CDK4途径介导肠毒性脆弱拟杆菌相关的结直肠癌致癌作用
长非编码 RNA(lncRNA)在肿瘤发生过程中起着关键作用,在肿瘤诊断和治疗方面具有潜力。肠毒性脆弱拟杆菌(ETBF)以产生肠毒素而闻名,它与人类肠道肿瘤发生有关,但其潜在机制尚未完全阐明。本研究旨在阐明lncRNA在ETBF诱导的肿瘤发生中的分子机制,重点研究LRP11-AS1在调节ETBF的结直肠癌发生中的作用。我们发现,与邻近的非肿瘤组织相比,结直肠癌(CRC)组织中 LRP11-AS1 的表达明显增加。在体外,暴露于 ETBF 的 CRC 细胞显示 LRP11-AS1 水平升高。从机理上讲,LRP11-AS1 与 miR-149-3p 竞争性结合,从而增强 CDK4 的表达。这些结果表明,LRP11-AS1 可能会促进 ETBF 相关的 CRC 癌变,并可作为 ETBF 相关 CRC 的治疗靶点和诊断生物标志物。
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来源期刊
Cancer gene therapy
Cancer gene therapy 医学-生物工程与应用微生物
CiteScore
10.20
自引率
0.00%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene and cellular therapies for cancer. The journal publishes original laboratory and clinical research papers, case reports and review articles. Publication topics include RNAi approaches, drug resistance, hematopoietic progenitor cell gene transfer, cancer stem cells, cellular therapies, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors, translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA & ribozymes), apoptosis; mechanisms and therapies, vaccine development, immunology and immunotherapy, DNA synthesis and repair. Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy and cellular therapies as applied to cancer research. Types of articles published include original research articles; case reports; brief communications; review articles in the main fields of drug resistance/sensitivity, gene therapy, cellular therapy, tumor suppressor and anti-oncogene therapy, cytokine/tumor immunotherapy, etc.; industry perspectives; and letters to the editor.
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