Pentacyclic triterpenoids with cytotoxic activity from the stems of Syzygium jambos (L.) Alston

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-12-12 DOI:10.1016/j.fitote.2024.106346

Zhilong Liu , Yuepei Huang , Jieting Chen , Lihua Peng , Weilin Qiao , Wei Li , De-an Guo

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Abstract

Phytochemical investigation of the stems of Syzygium jambos (L.) Alston resulted in the isolation of five new pentacyclic triterpenoids, including three oleananes (1, 2, and 5) and two ursanes (3 and 4), along with 23 known compounds (6–28). Their structures were elucidated by comprehensive spectroscopic analysis and chemical methods. All isolated compounds were evaluated for their cytotoxic activities against two lung carcinoma cell lines, H1975 and HCC827. Among them, compounds 2, 7, 11, 13–16, 18, and 23 exhibited significant cytotoxic activities against H1975 and/or HCC827 cells, with IC₅₀ values below 10 μM. Furthermore, the preliminary structure-activity relationships of these pentacyclic triterpenoids are also discussed.

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具有细胞毒性活性的五环三萜类化合物，来自茜草茎（L. Alston）。

杨木（Syzygium jambos）茎部植物化学研究Alston分离出5个新的五环三萜，包括3个齐墩烷（1、2和5）和2个熊烷（3和4），以及23个已知化合物（6-28）。通过综合光谱分析和化学方法对其结构进行了鉴定。所有分离得到的化合物对两种肺癌细胞株H1975和HCC827的细胞毒活性进行了评价。其中化合物2、7、11、13-16、18和23对H1975和/或HCC827细胞具有显著的细胞毒活性，IC50值均在10 μM以下。并初步讨论了这些五环三萜的构效关系。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.