Construction of antibacterial silicone rubber catheter modified with the biomass carbon dots and its properties.

Biomedical materials (Bristol, England) Pub Date : 2024-12-13 DOI:10.1088/1748-605X/ad9f03

Jing Liu, Ziyang Shao, Liyuan Liu, Qinke Zhao, Yongzhen Yang, Mei Niu, Li Zhang, Baoxia Xue

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Abstract

To endow silicone rubber (SR) catheter with antibacterial property, the SR catheter was modified with a new kind of biomass carbon dots (CDs) by the bulk modification to obtabin the SR/CDs catheter. The antimicrobial behavior and biocompatibility of SR/CDs catheter were analyzed by plate counting method, cytotoxicity test and in vivo animal experiments. The results showed that, SR/CDs catheter possessed antimicrobial properties, and the minimum inhibitory concentration of SR/CDs catheter was 20 mg/ml against Escherichia coli (E. coil) and Staphylococcus aureus (S. aureus). The antimicrobial mechanism of SR/CDs was further investigated, and it was found that the SR/CDs induced the production of reactive oxygen species in bacterial cells by disrupting the bacterial membrane through adsorption. In addition, in vivo experiments have shown that SR/CDs catheter owns good biosafety profile and reduces the risk of catheter-associated urinary tract infections by modu-lating inflammatory factors. Meanwhile, SR/CDs catheter can be produced in a simple production process using an extruder, which is expected to be used as a novelty type of catheter in the clinic. .

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