Construction of antibacterial silicone rubber catheter modified with the biomass carbon dots and its properties.

Biomedical materials (Bristol, England) Pub Date : 2024-12-30 DOI:10.1088/1748-605X/ad9f03

Jing Liu, Ziyang Shao, Liyuan Liu, Qinke Zhao, Yongzhen Yang, Mei Niu, Li Zhang, Baoxia Xue

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Abstract

To endow silicone rubber (SR) catheter with antibacterial property, the SR catheter was modified with a new kind of biomass carbon dots (CDs) by the bulk modification to obtabin the SR/CDs catheter. The antimicrobial behavior and biocompatibility of SR/CDs catheter were analyzed by plate counting method, cytotoxicity test andin vivoanimal experiments. The results showed that, SR/CDs catheter possessed antimicrobial properties, and the minimum inhibitory concentration of SR/CDs catheter was 20 mg ml^-1againstEscherichia coliandStaphylococcus aureus. The antimicrobial mechanism of SR/CDs was further investigated, and it was found that the SR/CDs induced the production of reactive oxygen species in bacterial cells by disrupting the bacterial membrane through adsorption. In addition,in vivoexperiments have shown that SR/CDs catheter owns good biosafety profile and reduces the risk of catheter-associated urinary tract infections by modulating inflammatory factors. Meanwhile, SR/CDs catheter can be produced in a simple production process using an extruder, which is expected to be used as a novelty type of catheter in the clinic.

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用生物质碳点改性的抗菌硅橡胶导管的构造及其性能。

为了使硅橡胶（SR）导管具有抗菌性能，采用生物质碳点（CDs）对SR导管进行本体改性，得到了SR/CDs导管。采用平板计数法、细胞毒性试验和动物体内实验分析SR/CDs导管的抗菌行为和生物相容性。结果表明，SR/CDs导管具有抗菌性能，对大肠杆菌（E. coil）和金黄色葡萄球菌（S. aureus）的最低抑制浓度为20 mg/ml。进一步研究了SR/CDs的抗菌机制，发现SR/CDs通过吸附破坏细菌膜，诱导细菌细胞产生活性氧。此外，体内实验表明，SR/CDs导管具有良好的生物安全性，并通过调节炎症因子降低导管相关性尿路感染的风险。同时，利用挤出机可以简单的生产出SR/CDs导管，有望成为临床应用的新型导管。。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical materials (Bristol, England)

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