Decline of antibodies to major viral and bacterial respiratory pathogens during the COVID-19 pandemic

Natalie Lorenz, Alex James, Tiaan Van Rooyen, Aimee Paterson, Ciara Ramiah, Lauren Carlton, Prachi Sharma, Michael G Baker, Richard Charlewood, Reuben McGregor, Nicole J Moreland
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Abstract

Surges in infections caused by respiratory pathogens have been documented in multiple settings after relaxation of pandemic restrictions. Antibodies to major antigens from respiratory syncytial virus and Group A Streptococcus waned significantly in a longitudinal adult cohort throughout the pandemic. This waning may have contributed to the pathogen-surges that followed.
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COVID-19 大流行期间主要病毒和细菌呼吸道病原体抗体的下降
大流行限制放宽后,呼吸道病原体引起的感染激增在多种情况下都有记录。在整个大流行期间,纵向成人队列中的呼吸道合胞病毒和 A 群链球菌主要抗原抗体明显减弱。这种减弱可能导致了随后的病原体激增。
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