Influence of some ergot alkaloids on the cerebral reduced glutathione.

Il Farmaco; edizione scientifica Pub Date : 1988-11-01
A Gorini, R Arnaboldi, L Vercesi, M Dossena
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Abstract

Dose-related changes of the reduced glutathione were evaluated in forebrains from male Wistar rats aged 10 months after chronic i.p. treatment for two months with the ergot alkaloids dihydroergocristine and dihydroergocriptine. The results indicate that, within a specific dose-range, the concentration of the cerebral reduced glutathione may be modified by exogenous intervention.

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麦角生物碱对大脑还原性谷胱甘肽的影响。
用麦角生物碱二氢麦角新碱和二氢麦角新碱慢性灌胃治疗两个月后,观察10月龄雄性Wistar大鼠前脑还原性谷胱甘肽的剂量相关变化。结果表明,在一定剂量范围内,外源性干预可改变脑还原性谷胱甘肽的浓度。
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