Xueting Sun , Xiaojin Zhang , Tingting Cao, Suqing Huang, Yu Dai, Fan Xia
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引用次数: 0
Abstract
Nanopore/nanochannel sensing is a promising analytical method in the fields of chemistry and biology. However, due to the interference of non-analytes in complex samples, directly analyzing un-pretreated samples through nanopores/nanochannels remains a great challenge. Here, we report a type of heterogeneous membrane by covering anodic aluminum oxide (AAO) cylindrical nanochannel porous membrane with graphene oxide/calcium alginate (GCA) hybrid hydrogel to reduce the interference of protein on the current detection signal. The hydrogel layer blocks the protein through steric hindrance, so that it will not block and affect the channel. The results show that when the GCA hydrogel is covered on the outer surface of AAO membrane, the interference of protein on the ion current decreases from 52 % to 5 %. Our work provides a strategy for reducing the interference of non-analytes in complex samples, and demonstrates the anti-interference function of hydrogels on nanopore/nanochannel sensing.
期刊介绍：
Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome.
Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.
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