Aiman Mahmoud, Raphael Tomi-Tricot, David Leitão, Philippa Bridgen, Anthony N Price, Alena Uus, Arnaud Boutillon, Andrew J Lawrence, Daniel Cromb, Paul Cawley, Maria Deprez, Enrico De Vita, Sharon L Giles, Mary A Rutherford, A David Edwards, Joseph V Hajnal, Tomoki Arichi, Shaihan J Malik
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引用次数: 0
Abstract
Purpose: To determine the expected range of NMR relaxation times (T1 and T2) in the neonatal brain at 7 T.
Methods: Data were acquired in a total of 40 examinations on infants in natural sleep. The cohort included 34 unique subjects with postmenstrual age range between 33 and 52 weeks and contained a mix of healthy individuals and those with clinical concerns. Single-slice T1 and T2 mapping protocols were used to provide measurements in white matter, cortex, cerebellum, and deep gray matter. Automatic image segmentation of a separate T2-weighted brain volume was used to define regions of interest for analysis.
Results: Linear regression was used to estimate relaxation times at term equivalent age (40 weeks postmenstrual age). with 95% confidence intervals was measured to be 2933 [2893, 2972] ms in white matter; 2653 [2604, 2701] ms in cerebellum; and 2486 [2439, 2532] ms in basal ganglia. was estimated as 119 [116, 121] ms in white matter, 99 [96, 102] ms in cerebellum, and 90 [89, 92] ms in basal ganglia. Most tissue-relaxation times showed a significant negative correlation with postmenstrual age, with the strongest correlation seen in cerebellum.
Conclusions: We describe neonatal brain tissue and age-specific T1 and T2 relaxation values at 7 T. The presented values differ substantially from both adult values at 7 T and neonate values measured at lower field strengths, and will be essential for pulse-sequence optimization for neonatal studies.
目的：确定新生儿7 T时脑核磁共振弛豫时间（T1和T2）的预期范围。方法：对40例处于自然睡眠状态的婴儿进行检查。该队列包括34名月经后年龄在33至52周之间的独特受试者，其中包括健康个体和有临床问题的个体。单片T1和T2制图方案提供白质、皮质、小脑和深部灰质的测量。使用单独的t2加权脑体积的自动图像分割来定义感兴趣的区域进行分析。结果：采用线性回归估计足月龄（经后40周）松弛时间。T 140周$$ {T}_1^{40 wk} $$与95% confidence intervals was measured to be 2933 [2893, 2972] ms in white matter; 2653 [2604, 2701] ms in cerebellum; and 2486 [2439, 2532] ms in basal ganglia. T 2 40 wk $$ {T}_2^{40 wk} $$ was estimated as 119 [116, 121] ms in white matter, 99 [96, 102] ms in cerebellum, and 90 [89, 92] ms in basal ganglia. Most tissue-relaxation times showed a significant negative correlation with postmenstrual age, with the strongest correlation seen in cerebellum.Conclusions: We describe neonatal brain tissue and age-specific T1 and T2 relaxation values at 7 T. The presented values differ substantially from both adult values at 7 T and neonate values measured at lower field strengths, and will be essential for pulse-sequence optimization for neonatal studies.
期刊介绍：
Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.
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