Ling Jin, Junwen Ge, Ying Cheng, Dan Deng, Pengjie Wan
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引用次数: 0
Abstract
Background: Atopic dermatitis (AD) is a prevalent allergic disease that significantly impacts pediatric health.
Objective: To comprehensively describe the global, regional, and national AD prevalence trends among children aged 0 to 14 years between 2000 and 2021.
Methods: Data from the Global Burden of Disease Study 2021 were used to analyze AD prevalence and case numbers. The annual average percentage change was calculated to assess prevalence trends.
Results: In 2021, global pediatric AD cases reached 72.4 million (95% uncertainty interval: 68.5-76.5), a 6.2% increase from 2000. Despite the rise in cases, the prevalence rate decreased on average by 0.15% (95% CI: 0.14%-0.16%). Regional prevalence varied widely, with the highest rates in Central Asia, high-income Asia Pacific, and Western Europe and the lowest in Sub-Saharan Africa. Nationally, the AD prevalence rates ranged from 1.50% in Rwanda to 10.67% in Mongolia. Between 2000 and 2021, 108 countries or territories showed a significant increase in AD prevalence, with the most notable rises in Russia, Ghana, and Latvia. In contrast, 48 countries, including the United States, Syria, and Japan, experienced a marked decrease in AD prevalence. Age and sex (male and female) patterns showed the highest prevalence in children aged 5 to 9 years, with girls having higher rates than boys across all age groups.
Conclusion: This study reveals complex global patterns in pediatric AD prevalence, underscoring the necessity of regionally tailored public health strategies and further research into the diverse causes of AD to enhance prevention and management efforts.
背景：特应性皮炎（AD）是一种常见的过敏性疾病，严重影响儿童健康。目的：综合描述2000年至2021年全球、区域和国家0-14岁儿童AD流行趋势。方法：使用2021年全球疾病负担研究的数据分析AD患病率和病例数。计算年平均百分比变化（AAPC）以评估流行趋势。结果：2021年，全球儿童AD病例达到7240万例（95%不确定区间68.5-76.5），较2000年增长6.2%。尽管病例有所增加，但患病率平均下降了0.15% （95% CI 0.14-0.16%）。区域患病率差异很大，中亚、高收入亚太地区和西欧的患病率最高，撒哈拉以南非洲的患病率最低。在全国范围内，AD患病率从卢旺达的1.50%到蒙古的10.67%不等。2000年至2021年期间，108个国家或地区的AD患病率显著上升，其中俄罗斯、加纳和拉脱维亚的上升最为显著。相比之下，包括美国、叙利亚和日本在内的48个国家的AD患病率明显下降。年龄和性别模式显示，5-9岁儿童的患病率最高，在所有年龄组中，女孩的患病率都高于男孩。结论：本研究揭示了儿童AD患病率的复杂全球模式，强调了有必要制定有针对性的区域公共卫生策略，并进一步研究AD的多种原因，以加强预防和管理工作。
期刊介绍：
Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.
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