Lipid Trafficking in Diverse Bacteria

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-12-16 DOI:10.1021/acs.accounts.4c00540
Jonathan Chiu-Chun Chou, Laura M. K. Dassama
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Abstract

Lipids are essential for life and serve as cell envelope components, signaling molecules, and nutrients. For lipids to achieve their required functions, they need to be correctly localized. This requires the action of transporter proteins and an energy source. The current understanding of bacterial lipid transporters is limited to a few classes. Given the diversity of lipid species and the predicted existence of specific lipid transporters, many more transporters await discovery and characterization. These proteins could be prime targets for modulators that control bacterial cell proliferation and pathogenesis.

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不同细菌中的脂质转运
脂质是生命所必需的,是细胞包膜成分、信号分子和营养物质。为了使脂质发挥其所需的功能,它们需要被正确定位。这需要转运蛋白的作用和能量来源。目前对细菌脂质转运体的了解仅限于几类。鉴于脂质种类的多样性和预测的特定脂质转运体的存在,更多的转运体有待发现和表征。这些蛋白可能是控制细菌细胞增殖和发病机制的调节剂的主要目标。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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