Solubilization of Hydrophobic Drugs in Cationic Glycerolipid Associates and Creation of Mesoporous Container Particles on These Bifunctional Templates

IF 1.4 4区化学 Q4 CHEMISTRY, PHYSICAL Colloid Journal Pub Date : 2024-12-17 DOI:10.1134/S1061933X2460074X

O. V. Dement’eva, E. M. Shishmakova, A. V. Ivchenko, M. S. Staltsov, A. A. Markova, V. M. Rudoy

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Abstract

It has been shown that associates of cationic glycerolipid (CGL), rac-N-{4-[(2-ethoxy-3-octadecyloxyprop-1-yl)oxycarbonyl]butyl}-N'-methylimidazolium iodide, which has a pronounced antitumor effect, can be used for the solubilization of two hydrophobic biologically active compounds (curcumin and capsaicin) and as templates in the sol–gel synthesis of silica mesoporous container particles (MCPs). The thermodynamic characteristics of solubilization are determined, and it is shown that this process contributes to a significant increase in the solubility of both hydrophobic drugs in water. The hydrolytic condensation of tetraethoxysilane in the presence of CGL associates containing curcumin or capsaicin leads to the formation of MCPs characterized by a narrow size distribution and a high content of encapsulated drugs. This combination of the stages of the synthesis and loading of MCPs is of undoubted interest in relation to the nanoencapsulation of cationic glycerolipids (including in combination with other drugs).

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疏水性药物在阳离子甘油酯类化合物中的溶解以及在这些双功能模板上生成介孔容器颗粒

研究表明，具有明显抗肿瘤作用的阳离子甘油脂（CGL）、rac-N-{4-[(2-乙氧基-3-十八烷氧基丙-1-基)氧羰基]丁基}-N'-甲基咪唑鎓碘化物的同系物可用于两种疏水性生物活性化合物（姜黄素和辣椒素）的增溶，并可作为溶胶-凝胶合成二氧化硅介孔容器颗粒（MCPs）的模板。测定了增溶的热力学特性，结果表明这一过程有助于显著提高这两种疏水性药物在水中的溶解度。四乙氧基硅烷在含有姜黄素或辣椒素的 CGL 同系物存在下发生水解缩合，形成的 MCPs 具有尺寸分布窄、包裹药物含量高的特点。将 MCPs 的合成和装载阶段结合起来，无疑对阳离子甘油三酯（包括与其他药物结合）的纳米包囊具有重要意义。

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来源期刊

Colloid Journal 化学-物理化学

CiteScore

2.20

自引率

18.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Colloid Journal (Kolloidnyi Zhurnal) is the only journal in Russia that publishes the results of research in the area of chemical science dealing with the disperse state of matter and surface phenomena in disperse systems. The journal covers experimental and theoretical works on a great variety of colloid and surface phenomena: the structure and properties of interfaces; adsorption phenomena and structure of adsorption layers of surfactants; capillary phenomena; wetting films; wetting and spreading; and detergency. The formation of colloid systems, their molecular-kinetic and optical properties, surface forces, interaction of colloidal particles, stabilization, and criteria of stability loss of different disperse systems (lyosols and aerosols, suspensions, emulsions, foams, and micellar systems) are also topics of the journal. Colloid Journal also includes the phenomena of electro- and diffusiophoresis, electro- and thermoosmosis, and capillary and reverse osmosis, i.e., phenomena dealing with the existence of diffusion layers of molecules and ions in the vicinity of the interface.