Comparison of 68Ga-FAPI PET CT/MRI and 18F-FDG PET/CT in metastatic lesions of gynecological cancers: a systematic review and head-to-head meta-analysis.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Acta radiologica Pub Date : 2024-12-15 DOI:10.1177/02841851241297836

Lixin Sun, Pan Hao, Ruchen Peng

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Abstract

Background: 68Ga-labled fibroblast activating protein inhibitor (68Ga-FAPI) represents a new and exciting positron emission tomography-computed tomography/magnetic resonance (PET-CT/MR) radiotracer.

Purpose: To compare the diagnostic efficacy of 68Ga-FAPI PET CT/MR and 18F-fluorodeoxyglucose (18F-FDG) PET/CT in metastatic lesions of gynecological cancers (GCs).

Material and methods: The PubMed, Embase, and Web of Science databases were thoroughly investigated from inception until 22 December 2023. A head-to-head contrast between 18F-FDG PET/CT as well as 68Ga-FAPI PET CT/MR for the assessment of GCs was presented by the included studies. A random variable model was employed to examine the sensitivity in detection of lymph node (LN) and peritoneal metastases (PM).

Results: The pooled sensitivity for 68Ga-FAPI PET CT/MR and 18F-FDG PET/CT in lymph node metastases (LNM) of GC were 0.98 (95% confidence interval [CI] = 0.86-1) and 0.85 (95% CI = 0.65-0.98), respectively, while the results about peritoneal metastases in ovarian cancer were 0.98 (95% CI = 0.93-1) and 0.71 (95% CI = 0.55-0.86). Compared with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in peritoneal involvement of ovarian cancer with a relative risk of 0.24 (95% CI = 0.09-0.40) and P = 0.002.

Conclusion: 68Ga-FAPI PET CT/MR displayed a superior sensitivity over 18F-FDG PET/CT in detecting metastatic lesions of ovarian cancer. However, there was insufficient evidence to favor the superiority of 68Ga-FAPI PET CT/MR in LNM of CC. Further studies are needed for evaluating primary and metastatic lesions of 68Ga-FAPI PET CT/MR in different GC.

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目的：比较68Ga-FAPI PET CT/MR和18F-氟脱氧葡萄糖（18F-FDG）PET/CT对妇科癌症（GCs）转移病灶的诊断效果：对PubMed、Embase和Web of Science数据库从开始到2023年12月22日的数据进行了全面调查。纳入的研究对 18F-FDG PET/CT 和 68Ga-FAPI PET CT/MR 评估 GCs 进行了头对头对比。结果显示，68Ga-FAPI正电子发射计算机断层扫描/MR对淋巴结转移和腹膜转移的敏感性高于18F-FDG正电子发射计算机断层扫描/CT：结果：68Ga-FAPI PET CT/MR和18F-FDG PET/CT对GC淋巴结转移（LNM）的汇总灵敏度分别为0.98（95%置信区间[CI] = 0.86-1）和0.85（95% CI = 0.65-0.98），而对卵巢癌腹膜转移的灵敏度分别为0.98（95% CI = 0.93-1）和0.71（95% CI = 0.55-0.86）。结论：与 18F-FDG PET/CT 相比，68Ga-FAPI PET CT/MR 对卵巢癌腹膜受累的敏感性更高，相对风险为 0.24（95% CI = 0.09-0.40），P = 0.002。然而，没有足够的证据表明68Ga-FAPI PET CT/MR在CC的LNM中更具优势。还需要进一步的研究来评估68Ga-FAPI PET CT/MR在不同GC中的原发病灶和转移病灶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta radiologica 医学-核医学

CiteScore

2.70

自引率

0.00%

发文量

170

审稿时长

3-8 weeks

期刊介绍： Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.