{"title":"Divergent functions of the evolutionarily conserved, yet seemingly dispensable, Wnt target, sp5.","authors":"Saurav Mohanty, Arne C Lekven","doi":"10.1016/j.diff.2024.100829","DOIUrl":null,"url":null,"abstract":"<p><p>The activation of sp5 in response to Wnt/β-catenin signaling is observed in many species during axis patterning, neural crest induction, maintenance and differentiation of stem cells. Indeed, the conserved response of sp5 orthologs to Wnt-mediated activation is the basis for this gene commonly being used as a readout for Wnt signaling activity. However, several seemingly conflicting findings regarding the function of sp5 in the context of Wnt signaling cast this gene in an enigmatic light. In this review, we examine current knowledge of sp5 structure and function, its relationship to Wnt signaling in varied contexts, and present perspectives on how progress on this interesting gene can move forward.</p>","PeriodicalId":50579,"journal":{"name":"Differentiation","volume":"141 ","pages":"100829"},"PeriodicalIF":2.2000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Differentiation","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.diff.2024.100829","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The activation of sp5 in response to Wnt/β-catenin signaling is observed in many species during axis patterning, neural crest induction, maintenance and differentiation of stem cells. Indeed, the conserved response of sp5 orthologs to Wnt-mediated activation is the basis for this gene commonly being used as a readout for Wnt signaling activity. However, several seemingly conflicting findings regarding the function of sp5 in the context of Wnt signaling cast this gene in an enigmatic light. In this review, we examine current knowledge of sp5 structure and function, its relationship to Wnt signaling in varied contexts, and present perspectives on how progress on this interesting gene can move forward.
期刊介绍：
Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal.
The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest.
The principal subject areas the journal covers are: • embryonic patterning and organogenesis
• human development and congenital malformation
• mechanisms of cell lineage commitment
• tissue homeostasis and oncogenic transformation
• establishment of cellular polarity
• stem cell differentiation
• cell reprogramming mechanisms
• stability of the differentiated state
• cell and tissue interactions in vivo and in vitro
• signal transduction pathways in development and differentiation
• carcinogenesis and cancer
• mechanisms involved in cell growth and division especially relating to cancer
• differentiation in regeneration and ageing
• therapeutic applications of differentiation processes.
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