{"title":"Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis.","authors":"Teng Zheng, Zhi Pei, Xiaojing Huang","doi":"10.2147/DDDT.S471602","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dexmedetomidine has received increasing attention for its sedative, analgesic, anxiolytic, anti-inflammatory and anti-stress effects in perioperative medicine. Numerous studies have been carried out to explore its influence on perioperative patients.</p><p><strong>Objective: </strong>This study aimed to identify the most influential literature, trends and hotspots in dexmedetomidine research by bibliometric analysis.</p><p><strong>Methods: </strong>Articles and reviews related to dexmedetomidine in perioperative medicine were collected from Web of Science Core Collection. VOSviewer and Citespace software were used for bibliometric analysis and data visualization.</p><p><strong>Results: </strong>A total of 1652 suitable publications were extracted from the database for analysis, including 1,497 articles and 155 reviews. The number of publications in the field of dexmedetomidine research has increased markedly since 2013, with China being the major contributor, followed by United States. <i>BMC Anesthesiology</i> published the highest number of papers on this topic. <i>Anesthesiology</i> ranked first in terms of average citations per paper and co-citation journal. Ji Fuhai was the most prolific author, and Ma Daqing was the most cited authors. The main hotspots during this period were \"elderly patients\", \"postoperative cognitive dysfunction\", \"injury\" and \"risk factors\".</p><p><strong>Conclusion: </strong>This study presents an overview of the development related to dexmedetomidine in perioperative medicine using bibliometric analysis. Dexmedetomidine research is thriving and expanding rapidly around the world. The effect of dexmedetomidine on cognitive function has been the latest research hotspot. To advance research in this field, more rigorous and scientific multi-center studies should be designed and further cooperation and academic exchange should be strengthened.</p>","PeriodicalId":11290,"journal":{"name":"Drug Design, Development and Therapy","volume":"18 ","pages":"6017-6029"},"PeriodicalIF":4.7000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648549/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Design, Development and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DDDT.S471602","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Dexmedetomidine has received increasing attention for its sedative, analgesic, anxiolytic, anti-inflammatory and anti-stress effects in perioperative medicine. Numerous studies have been carried out to explore its influence on perioperative patients.
Objective: This study aimed to identify the most influential literature, trends and hotspots in dexmedetomidine research by bibliometric analysis.
Methods: Articles and reviews related to dexmedetomidine in perioperative medicine were collected from Web of Science Core Collection. VOSviewer and Citespace software were used for bibliometric analysis and data visualization.
Results: A total of 1652 suitable publications were extracted from the database for analysis, including 1,497 articles and 155 reviews. The number of publications in the field of dexmedetomidine research has increased markedly since 2013, with China being the major contributor, followed by United States. BMC Anesthesiology published the highest number of papers on this topic. Anesthesiology ranked first in terms of average citations per paper and co-citation journal. Ji Fuhai was the most prolific author, and Ma Daqing was the most cited authors. The main hotspots during this period were "elderly patients", "postoperative cognitive dysfunction", "injury" and "risk factors".
Conclusion: This study presents an overview of the development related to dexmedetomidine in perioperative medicine using bibliometric analysis. Dexmedetomidine research is thriving and expanding rapidly around the world. The effect of dexmedetomidine on cognitive function has been the latest research hotspot. To advance research in this field, more rigorous and scientific multi-center studies should be designed and further cooperation and academic exchange should be strengthened.
背景：右美托咪定因其镇静、镇痛、抗焦虑、抗炎和抗应激等作用在围手术期医学中越来越受到重视。大量研究探讨其对围手术期患者的影响。目的：通过文献计量学分析，找出右美托咪定研究中最具影响力的文献、趋势和热点。方法：收集Web of Science Core Collection中有关右美托咪定在围手术期医学应用的相关文章和综述。使用VOSviewer和Citespace软件进行文献计量分析和数据可视化。结果：从数据库中共提取出适合分析的文献1652篇，其中文章1497篇，综述155篇。自2013年以来，右美托咪定研究领域的出版物数量显著增加，其中中国是主要贡献者，其次是美国。BMC麻醉学在这方面发表的论文数量最多。《麻醉学》在论文平均被引次数和共被引期刊上排名第一。季福海是最多产的作家，马大庆是被引用次数最多的作家。这一时期的主要热点是“老年患者”、“术后认知功能障碍”、“损伤”和“危险因素”。结论：本研究综述了右美托咪定在围手术期医学中的应用进展。右美托咪定的研究在世界范围内蓬勃发展并迅速扩大。右美托咪定对认知功能的影响一直是最新的研究热点。为推进该领域的研究，应设计更加严谨、科学的多中心研究，并进一步加强合作和学术交流。
期刊介绍：
Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications.
The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas.
Specific topics covered by the journal include:
Drug target identification and validation
Phenotypic screening and target deconvolution
Biochemical analyses of drug targets and their pathways
New methods or relevant applications in molecular/drug design and computer-aided drug discovery*
Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes)
Structural or molecular biological studies elucidating molecular recognition processes
Fragment-based drug discovery
Pharmaceutical/red biotechnology
Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products**
Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development
Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing)
Preclinical development studies
Translational animal models
Mechanisms of action and signalling pathways
Toxicology
Gene therapy, cell therapy and immunotherapy
Personalized medicine and pharmacogenomics
Clinical drug evaluation
Patient safety and sustained use of medicines.
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