The Evil Twins of Chronic Pelvic Pain Syndrome: A Systematic Review and Meta-Analysis on Interstitial Cystitis/Painful Bladder Syndrome and Endometriosis.

IF 2.7 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES Healthcare Pub Date : 2024-11-29 DOI:10.3390/healthcare12232403

Alessandra Inzoli, Marta Barba, Clarissa Costa, Valeria Carazita, Alice Cola, Martina Fantauzzi, Paolo Passoni, Serena Polizzi, Matteo Frigerio

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Abstract

Background: Chronic pelvic pain is a debilitating condition affecting quality of life. Endometriosis is one of the leading causes of CPP, but recent studies highlighted the role of interstitial cystitis/bladder pain syndrome (IC/PBS) in causing CPP. Only some studies addressed the coexistence of these two conditions, which seems more frequent than what is supposed, leading to diagnostic delays and unnecessary surgeries. This systematic review aimed to evaluate the estimate of the prevalence of the comorbidity of endometriosis and IC/PBS.

Methods: We performed a systematic review of the literature indexed on PubMed, Scopus, ISI Web of Science, and Cochrane using a combination of keywords and text words represented by "painful bladder syndrome", "endometriosis", "interstitial cystitis", and "bladder pain syndrome". We performed a meta-analysis of the results.

Results: The meta-analysis shows that the coexistence of endometriosis and IC/PBS in women with CPP ranged from 15.5% to 78.3%, which is higher than the prevalence of IC/PBS in the general population.

Conclusions: Prevalence data about the coexistence of endometriosis and IC/PBS are highly heterogeneous, probably due to the paucity of available data. However, in cases of endometriosis unresponsive to treatment, other reasons for CPP (such as IC/PBS) need to be ruled out.

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慢性盆腔疼痛综合征的邪恶双胞胎：关于间质性膀胱炎/膀胱疼痛综合征和子宫内膜异位症的系统回顾和元分析。

背景：慢性盆腔疼痛是一种影响生活质量的衰弱性疾病。子宫内膜异位症是CPP的主要病因之一，但最近的研究强调了间质性膀胱炎/膀胱疼痛综合征（IC/PBS）在CPP发病中的作用。只有一些研究解决了这两种情况的共存，这似乎比想象的更频繁，导致诊断延误和不必要的手术。本系统综述旨在评估子宫内膜异位症和IC/PBS合并症的患病率。方法：系统检索PubMed、Scopus、ISI Web of Science和Cochrane检索到的文献，采用以“膀胱疼痛综合征”、“子宫内膜异位症”、“间质性膀胱炎”和“膀胱疼痛综合征”为代表的关键词和文本词组合。我们对结果进行了荟萃分析。结果：meta分析显示，CPP女性中子宫内膜异位症和IC/PBS共存的比例为15.5% ~ 78.3%，高于一般人群中IC/PBS的患病率。结论：关于子宫内膜异位症和IC/PBS共存的患病率数据是高度异质性的，可能是由于可用数据的缺乏。然而，如果子宫内膜异位症对治疗无反应，则需要排除CPP的其他原因（如IC/PBS）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Healthcare Medicine-Health Policy

CiteScore

3.50

自引率

7.10%

发文量

审稿时长

47 days

期刊介绍： Healthcare (ISSN 2227-9032) is an international, peer-reviewed, open access journal (free for readers), which publishes original theoretical and empirical work in the interdisciplinary area of all aspects of medicine and health care research. Healthcare publishes Original Research Articles, Reviews, Case Reports, Research Notes and Short Communications. We encourage researchers to publish their experimental and theoretical results in as much detail as possible. For theoretical papers, full details of proofs must be provided so that the results can be checked; for experimental papers, full experimental details must be provided so that the results can be reproduced. Additionally, electronic files or software regarding the full details of the calculations, experimental procedure, etc., can be deposited along with the publication as “Supplementary Material”.