Relationship Between Metabolic Profile, Pain, and Functionality in Patients with Frozen Shoulder: A Cross-Sectional Study.

IF 2.4 4区医学 Q2 HEALTH CARE SCIENCES & SERVICES Healthcare Pub Date : 2024-12-04 DOI:10.3390/healthcare12232444

Dina Hamed Hamed, Celia Rodríguez-Pérez, Leo Pruimboom, Santiago Navarro-Ledesma

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Abstract

Background: Frozen shoulder (FS), or adhesive capsulitis, is a disabling condition characterized by pain and restricted shoulder mobility.

Aims: This study investigates the relationship between metabolic biomarkers-liver enzymes and thyroid function-and pain and shoulder functionality in patients with FS.

Methods: A total of 32 patients (22 women and 10 men) were included in this cross-sectional study. Participants underwent clinical evaluations and blood tests to assess metabolic biomarkers, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and thyroid-stimulating hormone (TSH). Pain and functionality were measured using the Shoulder Pain and Disability Index (SPADI). Correlation and multiple regression analyses were performed to assess the associations between biomarkers, pain, and functionality.

Results: Significant negative correlations were found between AST (r = -0.528, p = 0.029), ALT (r = -0.533, p = 0.027), GGT (r = -0.602, p = 0.011), and TSH (r = -0.556, p = 0.017) with total pain scores. A significant negative correlation was also observed between TSH and SPADI scores (r = -0.511, p = 0.039). Multiple regression analysis showed that GGT (β = -0.335, p = 0.008) and TSH (β = -0.298, p = 0.014) were the strongest predictors of pain. These findings suggest that metabolic biomarkers, particularly liver enzymes and thyroid function, play a significant role in the pathophysiology of frozen shoulder. The results highlight the importance of assessing these biomarkers for better understanding and managing pain and functionality in patients with FS.

Conclusions: Further research is needed to explore the underlying mechanisms and potential therapeutic targets.

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肩周炎患者的代谢特征、疼痛和功能之间的关系：一项横断面研究

背景：肩周炎（FS）或粘连性肩关节囊炎是一种以疼痛和肩关节活动受限为特征的致残性疾病。目的：本研究探讨了肩周炎患者的代谢生物标志物--肝酶和甲状腺功能--与疼痛和肩关节功能之间的关系：这项横断面研究共纳入 32 名患者（22 名女性和 10 名男性）。参与者接受了临床评估和血液检测，以评估代谢生物标志物，包括天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、γ-谷氨酰转移酶（GGT）和促甲状腺激素（TSH）。疼痛和功能使用肩部疼痛和残疾指数（SPADI）进行测量。为评估生物标志物、疼痛和功能之间的关联，进行了相关性和多元回归分析：结果：发现 AST（r = -0.528，p = 0.029）、ALT（r = -0.533，p = 0.027）、GGT（r = -0.602，p = 0.011）和 TSH（r = -0.556，p = 0.017）与疼痛总评分呈显著负相关。此外，还观察到 TSH 与 SPADI 评分之间存在明显的负相关（r = -0.511，p = 0.039）。多元回归分析表明，谷丙转氨酶（β = -0.335，p = 0.008）和促甲状腺激素（β = -0.298，p = 0.014）是疼痛的最强预测因子。这些发现表明，代谢生物标志物，尤其是肝酶和甲状腺功能，在肩周炎的病理生理学中起着重要作用。这些结果凸显了评估这些生物标志物对于更好地了解和管理肩周炎患者的疼痛和功能的重要性：需要进一步开展研究，探索其潜在机制和治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Healthcare Medicine-Health Policy

CiteScore

3.50

自引率

7.10%

发文量

审稿时长

47 days

期刊介绍： Healthcare (ISSN 2227-9032) is an international, peer-reviewed, open access journal (free for readers), which publishes original theoretical and empirical work in the interdisciplinary area of all aspects of medicine and health care research. Healthcare publishes Original Research Articles, Reviews, Case Reports, Research Notes and Short Communications. We encourage researchers to publish their experimental and theoretical results in as much detail as possible. For theoretical papers, full details of proofs must be provided so that the results can be checked; for experimental papers, full experimental details must be provided so that the results can be reproduced. Additionally, electronic files or software regarding the full details of the calculations, experimental procedure, etc., can be deposited along with the publication as “Supplementary Material”.