Factors influencing rates of unsupervised assessment of short-term learning in cognitively unimpaired adults.

IF 3.4 3区医学 Q2 NEUROSCIENCES Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI:10.1177/13872877241302491

Yen Ying Lim, Andrea Mills, Maya Norfolk, Emily Rosenich, Paul Maruff

{"title":"Factors influencing rates of unsupervised assessment of short-term learning in cognitively unimpaired adults.","authors":"Yen Ying Lim, Andrea Mills, Maya Norfolk, Emily Rosenich, Paul Maruff","doi":"10.1177/13872877241302491","DOIUrl":null,"url":null,"abstract":"Background: In older adults with preclinical Alzheimer's disease (AD), learning curves derived from validated psychological learning paradigms are reduced to an extent greater than impairment, or decline, on neuropsychological memory tests.Objective: This study aimed to examine how age, sex, education, mood, and general dementia risk, which also increases risk for preclinical AD, could influence learning curves.Methods: 1050 adults enrolled in the BetterBrains trial completed 10 blocks of ORCA-LLT learning trials over 5 days. Learning curves were derived from improvement in accuracy over trials. Participants also completed questionnaires of demography and mood, and the CAIDE risk score was computed for each participant.Results: Most participants (67%) completed ≥6 blocks of ORCA-LLT. Older age (d = 0.75), lower education (d = 0.50), and higher dementia risk (d = 0.36) were associated significantly with slower learning rates.Conclusions: In older adults, learning curves are influenced subtly by age, education, and dementia risk but not by sex or mood.","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"441-451"},"PeriodicalIF":3.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13872877241302491","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/16 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: In older adults with preclinical Alzheimer's disease (AD), learning curves derived from validated psychological learning paradigms are reduced to an extent greater than impairment, or decline, on neuropsychological memory tests.

Objective: This study aimed to examine how age, sex, education, mood, and general dementia risk, which also increases risk for preclinical AD, could influence learning curves.

Methods: 1050 adults enrolled in the BetterBrains trial completed 10 blocks of ORCA-LLT learning trials over 5 days. Learning curves were derived from improvement in accuracy over trials. Participants also completed questionnaires of demography and mood, and the CAIDE risk score was computed for each participant.

Results: Most participants (67%) completed ≥6 blocks of ORCA-LLT. Older age (d = 0.75), lower education (d = 0.50), and higher dementia risk (d = 0.36) were associated significantly with slower learning rates.

Conclusions: In older adults, learning curves are influenced subtly by age, education, and dementia risk but not by sex or mood.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

影响无监督短期学习评估率的因素。

背景：在患有临床前阿尔茨海默病（AD）的老年人中，在神经心理记忆测试中，从经过验证的心理学习范式得出的学习曲线的减少程度大于损伤或下降程度。目的：本研究旨在探讨年龄、性别、教育程度、情绪和一般痴呆风险（也会增加临床前AD的风险）如何影响学习曲线。方法：1050名成年人参加了BetterBrains试验，在5天内完成了10个ORCA-LLT学习试验。学习曲线来自于准确度的提高。参与者还完成了人口统计学和情绪调查问卷，并计算了每位参与者的CAIDE风险评分。结果：大多数参与者（67%）完成了≥6个区块的ORCA-LLT。年龄较大（d = 0.75）、受教育程度较低（d = 0.50）和痴呆风险较高（d = 0.36）与学习速度较慢显著相关。结论：在老年人中，学习曲线受年龄、教育程度和痴呆风险的微妙影响，但不受性别或情绪的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.