{"title":"Mertk Signaling and Immune Regulation in T cells.","authors":"Christopher Varsanyi, Raymond B Birge","doi":"10.1093/jleuko/qiae253","DOIUrl":null,"url":null,"abstract":"<p><p>While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host anti-tumor immunity. A recent study shows that Mertk expressed on human T cells, including CD8+ T cells and differentiated central memory T cells, has a co-stimulatory function for the T Cell Receptor (TCR). These new findings reveal the complexity and diversification of Mertk in immune regulation and its implications to cancer therapeutics.</p>","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiae253","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host anti-tumor immunity. A recent study shows that Mertk expressed on human T cells, including CD8+ T cells and differentiated central memory T cells, has a co-stimulatory function for the T Cell Receptor (TCR). These new findings reveal the complexity and diversification of Mertk in immune regulation and its implications to cancer therapeutics.
TAM家族成员，尤其是Mertk，被广泛认为是一种抑制性受体，可驱动髓系细胞的排泄和免疫清除，但在免疫肿瘤学中，它们已成为有希望的靶点，有助于刺激宿主的抗肿瘤免疫。最近的一项研究表明，在人类 T 细胞（包括 CD8+ T 细胞和分化的中央记忆 T 细胞）上表达的 Mertk 对 T 细胞受体（TCR）具有协同刺激功能。这些新发现揭示了 Mertk 在免疫调节中的复杂性和多样性及其对癌症治疗的影响。
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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