Infrapatellar Fat Pad-Derived Non-Cellular Products in Therapy for Musculoskeletal Diseases: A Scoping Review.

IF 1.4 Q3 ORTHOPEDICS Orthopedic Reviews Pub Date : 2024-12-14 eCollection Date: 2024-01-01 DOI:10.52965/001c.125841
Aditya Fuad Robby Triangga, Widya Asmara, Rahadyan Magetsari, Indra Bachtiar, Dandy Ardhan Fazatamma, Paramita Ayu Saraswati, A Faiz Huwaidi, Yohanes Widodo Wirohadidjojo
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Abstract

Background: The complex nature of musculoskeletal diseases and the limitations of existing treatments have driven researchers to explore innovative solutions, particularly those involving stem cells and their derivatives. The utilization of the IPFP as a source of MSC-derived non-cellular products for the treatment of musculoskeletal diseases has gained recognition in recent years. This study aimed to identify the progress of IPFP-derived acellular biologics use in the treatment of orthopedic conditions such as osteoarthritis and ligament and/or tendon injuries.

Methods: A literature search was conducted through PubMed, Scopus and Google Scholar databases including studies over the past 10 years. This scoping review includes studies discussing the development of intercellular messenger signaling molecules (non-cellular products) in the form of exosomes, secretomes, and conditioned medium derived from the IPFP in the management of musculoskeletal diseases. The PRISMA-ScR guidelines were utilized in this review.

Results: Six studies met the inclusion criteria. Most studies reported the beneficial anti-inflammatory effects of IPFP-derived noncellular products in musculoskeletal conditions. The effects of IPFP-derived exosomes, secretomes, and conditioned medium administration are mostly reported in microscopic changes through cellular and matrix changes. Additionally, quantitative analyses involved assessing levels of anti-inflammatory and pro-inflammatory markers, proteins, fatty acids, and gene expression.

Conclusions: The use of IPFP-derived non-cellular products has shown significant promise in the regenerative therapy for musculoskeletal diseases. These agents have demonstrated beneficial effects, particularly in reducing inflammation, promoting cellular changes, and enhancing tissue regeneration. However, further research is needed to fully understand the characteristics and explore the potential applications of IPFP-derived non-cellular products in musculoskeletal cases.

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髌下脂肪垫衍生的非细胞产品在肌肉骨骼疾病治疗中的应用:综述
背景:肌肉骨骼疾病的复杂性和现有治疗方法的局限性促使研究人员探索创新的解决方案,特别是那些涉及干细胞及其衍生物的解决方案。近年来,利用IPFP作为骨髓间充质干细胞衍生的非细胞产品治疗肌肉骨骼疾病已得到认可。本研究旨在确定ipfp衍生的脱细胞生物制剂在骨关节炎、韧带和/或肌腱损伤等骨科疾病治疗中的应用进展。方法:通过PubMed、Scopus和谷歌Scholar数据库检索近10年的相关文献。这篇综述包括讨论细胞间信使信号分子(非细胞产物)的发展,其形式为外泌体、分泌体和条件培养基,源自IPFP在肌肉骨骼疾病管理中的应用。本综述采用PRISMA-ScR指南。结果:6项研究符合纳入标准。大多数研究报道了ipfp衍生的非细胞产品在肌肉骨骼疾病中的有益抗炎作用。ipfp衍生的外泌体、分泌体和条件培养基的作用主要是通过细胞和基质的微观变化来报道的。此外,定量分析包括评估抗炎和促炎标志物、蛋白质、脂肪酸和基因表达的水平。结论:使用ipfp衍生的非细胞产品在肌肉骨骼疾病的再生治疗中显示出显著的前景。这些药物已被证明具有有益的效果,特别是在减少炎症、促进细胞变化和增强组织再生方面。然而,需要进一步的研究来充分了解ipfp衍生的非细胞产品的特点,并探索其在肌肉骨骼病例中的潜在应用。
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来源期刊
Orthopedic Reviews
Orthopedic Reviews ORTHOPEDICS-
CiteScore
2.70
自引率
4.80%
发文量
122
审稿时长
10 weeks
期刊介绍: Orthopedic Reviews is an Open Access, online-only, peer-reviewed journal that considers articles concerned with any aspect of orthopedics, as well as diagnosis and treatment, trauma, surgical procedures, arthroscopy, sports medicine, rehabilitation, pediatric and geriatric orthopedics. All bone-related molecular and cell biology, genetics, pathophysiology and epidemiology papers are also welcome. The journal publishes original articles, brief reports, reviews and case reports of general interest.
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