{"title":"Identifying Risk Factors Associated With False-Negative Results in US-Guided Percutaneous Transthoracic Needle Lung Biopsy of Subpleural Pulmonary Lesions.","authors":"Jiawei Yi, Mengjun Shen, Junhui He, Runhe Xia, Xinyu Zhao, Yin Wang","doi":"10.1111/1759-7714.15506","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aims to investigate the factors influencing false-negative results in ultrasound-guided percutaneous transthoracic needle lung biopsy results (US-PTLB).</p><p><strong>Materials and methods: </strong>This ambispective cohort study included patients with subpleural pulmonary lesions who underwent US-PTLB with benign pathological findings between April 2017 and June 2022 (retrospective cohort) and between July 2022 and October 2022 (prospective cohort). In the retrospective cohort, comparative and logistic regression analyses were performed to identify independent risk factors for false-negative biopsy results. Stratified analyses based on these risk factors were performed in the prospective cohort.</p><p><strong>Results: </strong>The retrospective cohort included 1747 (true-negative: false-negative, 1321:426) patients with negative biopsy results, which were analyzed by comparative and logistic regression analyses, and the results demonstrated that advanced age (> 56 years) (OR = 1.08, 95% CI: 1.07-1.09), small-sized lesions (< 3 cm) (OR = 1.80, 95% CI: 1.38-2.34), lesions with necrosis (OR = 3.00, 95% CI: 2.29-3.92), contrast-enhanced ultrasound (CEUS) showing hyper-enhancement (OR = 5.87, 95% CI: 4.09-8.42) or iso-enhancement (OR = 2.81, 95% CI: 2.05-3.83), and the presence of hemoptysis (OR = 11.82, 95% CI: 5.16-27.08) or pneumothorax (OR = 7.90, 95% CI: 2.89-21.58) during the puncture were independent predictors of false-negative US-PTLB results. The results of stratified analyses in the prospective cohort were consistent with the retrospective cohort.</p><p><strong>Conclusion: </strong>Risk factors associated with false-negative results included advanced age (> 56 years), small-sized lesion (< 3 cm), presence of necrosis in the lesion, CEUS showing hyper-enhancement or iso-enhancement of the lesion, and hemoptysis or pneumothorax during puncture.</p><p><strong>Trial registration: </strong>Number: ChiCTR2000029749.</p>","PeriodicalId":23338,"journal":{"name":"Thoracic Cancer","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thoracic Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/1759-7714.15506","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
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Abstract
Background: This study aims to investigate the factors influencing false-negative results in ultrasound-guided percutaneous transthoracic needle lung biopsy results (US-PTLB).
Materials and methods: This ambispective cohort study included patients with subpleural pulmonary lesions who underwent US-PTLB with benign pathological findings between April 2017 and June 2022 (retrospective cohort) and between July 2022 and October 2022 (prospective cohort). In the retrospective cohort, comparative and logistic regression analyses were performed to identify independent risk factors for false-negative biopsy results. Stratified analyses based on these risk factors were performed in the prospective cohort.
Results: The retrospective cohort included 1747 (true-negative: false-negative, 1321:426) patients with negative biopsy results, which were analyzed by comparative and logistic regression analyses, and the results demonstrated that advanced age (> 56 years) (OR = 1.08, 95% CI: 1.07-1.09), small-sized lesions (< 3 cm) (OR = 1.80, 95% CI: 1.38-2.34), lesions with necrosis (OR = 3.00, 95% CI: 2.29-3.92), contrast-enhanced ultrasound (CEUS) showing hyper-enhancement (OR = 5.87, 95% CI: 4.09-8.42) or iso-enhancement (OR = 2.81, 95% CI: 2.05-3.83), and the presence of hemoptysis (OR = 11.82, 95% CI: 5.16-27.08) or pneumothorax (OR = 7.90, 95% CI: 2.89-21.58) during the puncture were independent predictors of false-negative US-PTLB results. The results of stratified analyses in the prospective cohort were consistent with the retrospective cohort.
Conclusion: Risk factors associated with false-negative results included advanced age (> 56 years), small-sized lesion (< 3 cm), presence of necrosis in the lesion, CEUS showing hyper-enhancement or iso-enhancement of the lesion, and hemoptysis or pneumothorax during puncture.
期刊介绍：
Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society.
The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.
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