Microwave-Accelerated Synthesis of Novel Triphosphate Nucleoside Prodrugs: Expanding the Therapeutic Arsenal of Anticancer Agents

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-12-17 DOI:10.1021/acs.orglett.4c04379

Camille Tisnerat, Samuele Di Ciano, Fabrizio Pertusati, Michaela Serpi

引用次数: 0

Abstract

In this study, we report for the first time a microwave-accelerated synthesis of purine and pyrimidine nucleoside triphosphate prodrugs, whose γ phosphate is masked with an aryloxy moiety and an amino acid ester (γ-ProTriP). The synthetic utility of this method is illustrated by the synthesis of triphosphate prodrugs of clofarabine and gemcitabine, two FDA-approved anticancer drugs. These new prodrugs showed good chemical and rat serum stability. Remarkably the clofarabine prodrug showed significant cytotoxicity against a panel of cancer cell lines.

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在本研究中，我们首次报道了微波加速合成嘌呤和嘧啶核苷三磷酸原药的方法，γ 磷酸被芳基氧基和氨基酸酯（γ-ProTriP）掩蔽。美国 FDA 批准的两种抗癌药物氯法拉滨和吉西他滨的三磷酸原药的合成说明了这种方法的合成用途。这些新原药显示出良好的化学稳定性和大鼠血清稳定性。值得注意的是，氯法拉滨原药对一组癌细胞株具有显著的细胞毒性。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.

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