Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-12-18 DOI:10.1002/alz.14291

Courtney M. Kloske, Simin Mahinrad, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Brittany Butts, Maria C. Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft, Sandro Da Mesquita, Luke C. Dabin, Davangere Devanand, Violeta Duran-Laforet, Wassim Elyaman, Elizabeth E. Evans, Patricia Fitzgerald-Bocarsly, Kate E. Foley, Ashley S. Harms, Michael T. Heneka, Soyon Hong, Yu-Wen A. Huang, Stephanie Jackvony, Laijun Lai, Yann Le Guen, Cynthia A. Lemere, Shane A. Liddelow, Alfonso Martin-Peña, Anna G. Orr, Francisco J. Quintana, Grace D. Ramey, Jessica E. Rexach, Stacey J. S. Rizzo, Claire Sexton, Alice S. Tang, Jose G. Torrellas, Andy P. Tsai, Lynn van Olst, Keenan A. Walker, Whitney Wharton, Malú Gámez Tansey, Donna M Wilcock

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Abstract

The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated. In March of 2023, the Alzheimer's Association convened the Alzheimer's Association International Conference (AAIC), Advancements: Immunity, to discuss the roles of the immune system in ADRD. A wide range of topics were discussed, such as animal models that replicate human pathology, immune-related biomarkers and clinical trials, and lessons from other fields describing immune responses in neurodegeneration. This manuscript presents highlights from the conference and outlines avenues for future research on the roles of immunity in neurodegenerative disorders.

Highlights

The immune system plays a central role in the pathogenesis of Alzheimer's disease.

The immune system exerts numerous effects throughout the brain on amyloid-beta, tau, and other pathways.

The 2023 AAIC, Advancements: Immunity, encouraged discussions and collaborations on understanding the role of the immune system.

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免疫和痴呆研究的进展：2023 AAIC进展：免疫会议的亮点

免疫系统在神经退行性疾病的发生和发展中起着关键作用。虽然大脑常驻免疫细胞介导的神经炎症和外周免疫细胞（如T细胞）浸润到大脑中已被证明是阿尔茨海默病（AD）病理的重要因素，但在AD和相关痴呆（ADRD）的背景下，大脑免疫反应的性质和程度仍不清楚。此外，外周免疫系统在驱动ADRD病理中的作用仍未完全阐明。2023年3月，阿尔茨海默病协会召开了阿尔茨海默病协会国际会议（AAIC），会议主题为“进展：免疫”，讨论免疫系统在ADRD中的作用。会议讨论了广泛的主题，如复制人类病理的动物模型，免疫相关生物标志物和临床试验，以及从其他领域描述神经变性免疫反应的经验教训。这份手稿介绍了会议的亮点，并概述了免疫在神经退行性疾病中的作用的未来研究途径。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.