Phenylboronic Acid-Modified pH/Glucose Dual-Responsive Polymeric Micelles for Targeted Anticancer Drug Delivery

IF 5.5 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-11-20 DOI:10.1021/acsanm.4c04679

Sifang Zhao, Fengjiao Chen, Xianwu Chen, Hongze Liang, Hui Tan* and Lingling Zhao*,

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Abstract

The tumor microenvironment is characterized by several hallmarks such as an acidic pH and high glucose levels in tumor tissues and increased expression of specific proteins and/or sugars on the surface of tumor cells. These unique hallmarks of tumors can be considered in the design of multifunctional drug delivery nanosystems to improve the efficiency of tumor therapy through targeted drug delivery and specific drug release in the tumor tissue. In this study, phenylboronic acid-modified pH- and glucose-responsive polymer micelles were designed for the targeted delivery of anticancer drugs. The polymeric micelles demonstrated prolonged and pH/glucose-triggered drug release and enhanced cellular internalization by B16F10 cells through a receptor-mediated endocytosis pathway. The polymeric micellar system could inhibit the proliferation of B16F10 cells with IC₅₀ values lower than those of unmodified micelles. In addition, the polymeric micellar system could markedly suppress cell migration, colony formation, and invasion and promote the apoptosis of B16F10 cells, indicating good anticancer efficiency in vitro. Therefore, this polymeric nanocarrier provides a potential platform for targeted anticancer therapy.

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用于靶向递送抗癌药物的苯硼酸改性 pH/葡萄糖双响应聚合物胶束

肿瘤微环境具有几个特征，如肿瘤组织中的酸性pH值和高葡萄糖水平以及肿瘤细胞表面特定蛋白质和/或糖的表达增加。肿瘤的这些独特特征可以在设计多功能药物递送纳米系统时加以考虑，通过靶向药物递送和肿瘤组织中的特异性药物释放来提高肿瘤治疗的效率。在这项研究中，苯硼酸修饰的pH-和葡萄糖反应性聚合物胶束被设计用于靶向递送抗癌药物。聚合物胶束表现出延长和pH/葡萄糖触发的药物释放，并通过受体介导的内吞途径增强B16F10细胞的细胞内化。聚合物胶束体系对B16F10细胞的增殖有抑制作用，但IC50值低于未修饰胶束体系。此外，该聚合物胶束体系能显著抑制B16F10细胞的迁移、集落形成和侵袭，促进B16F10细胞的凋亡，显示出良好的体外抗癌效果。因此，这种聚合物纳米载体为靶向抗癌治疗提供了一个潜在的平台。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.