Clinical Manifestations of Anti-GABA-B Receptor Encephalitis: A Case Series.

IF 0.9 3区医学 Q4 NEUROSCIENCES Neurology India Pub Date : 2024-11-01 Epub Date: 2024-12-17 DOI:10.4103/neurol-india.Neurol-India-D-23-00496

Jeeva P Jiju, Sneha Santhosh, Chirag S Lalwani, Smrithi S Thampi, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Saraf U Umesh, Gopikrishnan Unnikrishnan, Anandkumar Anandakuttan, Annamma Mathai, Jyothi V Leelamani, Parameswaran Krishnan, John J Vaidya, Bineesh Chemminikkara

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Abstract

Anti γ aminobutyric acid B(GABA B) receptor encephalitis is a rare form of autoimmune encephalitis. Our aim is to study the clinical characteristics and treatment outcomes of anti GABA B receptor encephalitis. This is a retrospective case series from the Neuroimmunology laboratory of Amrita Institute of Medical Sciences, Kochi, Kerala, India from 2016 to 2021. A total of four cases (two males, two females, age range: 13-80 years) tested positive for GABA B antibody during the study period. The clinical manifestations of anti GABA B receptor encephalitis found in our patients consisted of seizures, cognitive function decline (especially recent memory), and behavioral abnormalities. No malignancies were encountered. Patients were treated with steroids and immunoglobulins and showed an improvement in behavioral and cognitive function. However, one patient succumbed to illness while being treated with plasma exchange, and two other patients died at a later date due to other causes.

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抗gaba - b受体脑炎的临床表现：一个病例系列。

抗γ氨基丁酸B（GABA B）受体脑炎是一种罕见的自身免疫性脑炎。我们的目的是研究抗GABA B受体脑炎的临床特点和治疗效果。这是2016年至2021年印度喀拉拉邦高知Amrita医学科学研究所神经免疫学实验室的回顾性病例系列。研究期间共有4例（男2例，女2例，年龄13 ~ 80岁）GABA B抗体检测呈阳性。抗GABA B受体脑炎的临床表现为癫痫发作、认知功能下降（尤其是近期记忆）和行为异常。未见恶性肿瘤。患者接受类固醇和免疫球蛋白治疗，表现出行为和认知功能的改善。然而，一名患者在接受血浆置换治疗时因病死亡，另外两名患者因其他原因死亡。

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来源期刊

Neurology India 医学-神经科学

CiteScore

1.60

自引率

70.40%

发文量

434

审稿时长

2 months

期刊介绍： Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.