Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2025-01-01 DOI:10.1016/j.prostaglandins.2024.106939

Jitendra Gupta , Munthar Kadhim Abosaoda , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Alireza Hadpoori

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Abstract

Background

There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.

Methods

PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024. Data from RCTs were pooled using the generic inverse variance method and expressed as weighted mean differences (WMD) with 95 % confidence interval (CIs).

Results

Pooled data from 38 RCTs reporting patient outcomes were evaluated for mean effects. Results indicated that soluble fiber significantly altered TG (WMD: −16.97 mg/dL, 95 % CI: −29.16 to −4.78, P = 0.021), HDL-C (WMD: 1.74 mg/dL, 95 % CI: 1.02–2.46, P < 0.001), LDL-C (WMD: −11.14 mg/dL, 95 % CI: −15.41 to −6.87, P < 0.001), and TC (WMD: −13.87 mg/dL, 95 % CI: −17.99 to −9.75, P = 0.027).

Conclusions

Soluble fiber supplementation has the potential to improve lipid profile in patients with T2DM, and may provide a feasible approach for improving metabolic health in T2DM patients.

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补充可溶性纤维对2型糖尿病患者血脂参数的影响：随机对照试验的系统回顾和荟萃分析

背景：关于可溶性纤维对2型糖尿病（T2DM）患者血脂的影响，现有文献尚未达成共识。本研究对随机对照试验进行系统回顾和荟萃分析，旨在评估可溶性纤维对T2DM患者甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的影响。方法：检索截至2024年5月4日的rct，检索PubMed/MEDLINE、Scopus和ISI Web of sciences。随机对照试验的数据采用通用反方差法合并，并以加权平均差（WMD）表示，置信区间为95% %。结果：对38项报告患者结局的随机对照试验的汇总数据进行平均效果评估。结果表明，可溶性纤维显著改变了TG （WMD: -16.97 mg/dL, 95 % CI: -29.16 ~ -4.78, P = 0.021）和HDL-C （WMD: 1.74 mg/dL, 95 % CI: 1.02 ~ 2.46, P ）。结论：补充可溶性纤维具有改善T2DM患者血脂的潜力，可能为改善T2DM患者代谢健康提供一种可行的途径。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.