A comparative analysis of platelet-rich plasma alone versus combined with extracorporeal shockwave therapy in athletes with patellar tendinopathy and knee pain: a randomized controlled trial.

Shun-Wun Jhan, Kuan-Ting Wu, Wen-Yi Chou, Po-Cheng Chen, Ching-Jen Wang, Wen-Chiung Huang, Jai-Hong Cheng
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Abstract

Background: Patellar tendinopathy, also known as jumper's knee, can significantly impact the quality of daily life for patients due to the associated pain. A randomized controlled trial was investigated the clinical, sonographic, and serum cytokine markers in patellar tendinopathy of athletes following platelet-rich plasma (PRP) or PRP with extracorporeal shockwave therapy (ESWT) treatments. Our aims to investigate and compare therapeutic effects of PRP versus a combination of PRP with ESWT for treating patellar tendinopathy.

Methods: A total of 33 athletes with patellar tendinopathy were randomized into two groups. PRP + Sham (PS) group received intraarticular injection of autologous PRP (5 mL) once and sham ESWT. PRP + ESWT (PE) group received intraarticular injection of autologous PRP once and after 1 week ESWT (0.2 mJ/mm2 energy flux density, 1350 impulses, 4 Hz) once. All patients were followed up for 1 year.

Results: Autologous PRP injection and its combination with ESWT are both effective treatments for chronic patellar tendinopathy in athletes. PRP combined with ESWT resulted in faster reduction of knee pain than PRP alone at the 1-month follow-up. Serum IL-33 showed no significant difference at the 12-month follow-up. Levels of interleukin (IL)-6, IL-15, and IL-17 increased at the 12-month follow-up, potentially due to the additional training. However, the athletes did not report any discomfort or injuries, and no abnormalities were detected by ultrasonography after study. We demonstrated improvements in pain and functional scores, as well as knee injury protection in athletes, following 12 months of PRP and PRP with ESWT treatments.

Conclusions: The study analyzed the therapeutic effect of PRP injection alone and combining PRP injection with ESWT for chronic patellar tendinopathy. Our results showed that combined treatment can facilitate the pain relief early than PRP alone and is a safety treatment modality. No adverse effect was noted in our study. Trial registration Research registry and the registration number is researchregistry9518. Registered 14 September 2023. https://www.researchregistry.com/browse-the-registry#home/registrationdetails/650263e4f549fd00282a338c/ . The level of evidence is level II.

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对患有髌骨肌腱病和膝关节疼痛的运动员单独使用富血小板血浆与结合使用体外冲击波疗法的比较分析:随机对照试验。
背景:髌骨肌腱病变,也被称为跳腿膝,由于相关的疼痛会显著影响患者的日常生活质量。一项随机对照试验研究了富血小板血浆(PRP)或PRP联合体外冲击波治疗(ESWT)后运动员髌骨肌腱病变的临床、超声和血清细胞因子标志物。我们的目的是研究和比较PRP与PRP联合ESWT治疗髌骨肌腱病变的疗效。方法:将33例髌骨肌腱病变运动员随机分为两组。PRP + Sham (PS)组给予自体PRP (5 mL)关节内注射1次,同时给予假ESWT。PRP + ESWT (PE)组关节内注射自体PRP 1次,1周后ESWT (0.2 mJ/mm2能量通量密度,1350脉冲,4 Hz) 1次。所有患者均随访1年。结果:自体PRP注射及联合ESWT治疗运动员慢性髌骨肌腱病变均有较好的疗效。在1个月的随访中,PRP联合ESWT比单独PRP更快地减轻了膝关节疼痛。随访12个月,血清IL-33无显著差异。在12个月的随访中,白细胞介素(IL)-6、IL-15和IL-17的水平升高,可能是由于额外的训练。然而,运动员没有报告任何不适或损伤,研究后超声检查未发现异常。我们证明了在PRP和PRP与ESWT治疗12个月后,运动员的疼痛和功能评分以及膝关节损伤保护得到改善。结论:本研究分析了单纯PRP注射及PRP注射联合ESWT治疗慢性髌骨肌腱病变的疗效。我们的结果表明,联合治疗比单独PRP更早缓解疼痛,是一种安全的治疗方式。本研究未发现不良反应。试验注册研究注册,注册号为researchregistry9518。注册于2023年9月14日。/ registrationdetails / 650263 e4f549fd00282a338c / https://www.researchregistry.com/browse-the-registry回家。证据等级为二级。
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CiteScore
6.50
自引率
0.00%
发文量
42
审稿时长
19 weeks
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