Establishment of post-percutaneous coronary intervention (post-PCI) clinic in Thailand

IF 1.3 Q4 PHARMACOLOGY & PHARMACY Journal of the American College of Clinical Pharmacy : JACCP Pub Date : 2024-08-28 DOI:10.1002/jac5.2020
Thidarat Manapattanasatien B.S., Nuanchan Phanthumetamat M.S., Chanikarn Kanaderm M.D., Wirash Kehasukcharoen M.D., Wipharak Rattanavipanon B.S., Surakit Nathisuwan Pharm.D., Thanaputt Chaiyasothi Pharm.D.
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Abstract

Background

Although significant advancements have been made in the acute management of acute coronary syndrome (ACS) in Thailand, there is a need for improvement in the longitudinal care post cardiac stenting.

Objective

The study aimed to describe the successful establishment of the first post-percutaneous coronary intervention (PCI) clinic in Thailand and its preliminary impact compared with historical controls.

Method

A multidisciplinary outpatient clinic entitled the “post-PCI clinic,” consisting of cardiologists, nurses, clinical pharmacists, a physical therapist, and a dietitian, was established in 2016 to provide longitudinal care for patients who underwent cardiac stenting at a tertiary care hospital. A standard care pathway, along with the clinic's standard operating protocols, was designed and implemented. A pre-post intervention, quasi-experimental study, was conducted to compare the usage rate of secondary prevention medications between patients enrolled in the post-PCI clinic (January–April 2016) and historical controls (January–June 2015) at month 6 after hospital discharge.

Results

During January–April 2016, 91 patients were enrolled in the post-PCI clinic, with a mean age of 59.2 ± 11.9 years and 65.9% being male. Of these patients, 94.5% presented with ST-segment elevation myocardial infarction. Regarding the PCI procedure, 90.1% underwent primary PCI, and 9.9% underwent elective PCI. Almost all patients (98.9%) received drug-eluting stent placement, except for one. Compared with the historical control group, the usage rates of Angiotensin-converting enzyme (ACE) inhibitors/Angiotensin Receptor Blockers (ACEIs/ARBs) (94.5% vs. 76.5%; p < 0.001), beta-blockers (93.4% vs. 81.4%; p = 0.013), and high-intensity statins (90.1% vs. 33.3%; p < 0.001) were higher in the post-PCI clinic group 6 months after discharge. The three most common interventions by clinical pharmacists were recommendations to initiate new therapy (52.4%), suggestions to adjust dosage regimen (36.7%) and suggestions to change therapy (10.9%).

Conclusion

The post-PCI clinic led to a higher usage rate of secondary prevention medications compared with historical controls.

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泰国经皮冠状动脉介入治疗(pci)后诊所的建立
背景虽然泰国在急性冠脉综合征(ACS)的急性管理方面取得了重大进展,但心脏支架植入术后的纵向护理仍需改进。目的本研究旨在描述泰国第一家经皮冠状动脉介入治疗(PCI)诊所的成功建立及其与历史对照的初步影响。方法于2016年建立多学科门诊“pci后诊所”,由心脏病专家、护士、临床药师、物理治疗师和营养师组成,为在三级医院接受心脏支架植入术的患者提供纵向护理。设计并实施了一个标准的护理途径,以及诊所的标准操作协议。通过一项干预前后准实验研究,比较pci术后门诊入组患者(2016年1月- 4月)与历史对照(2015年1月- 6月)出院后第6个月二级预防药物的使用率。结果2016年1 - 4月入组pci术后临床91例,平均年龄59.2±11.9岁,男性65.9%。其中94.5%的患者表现为st段抬高型心肌梗死。关于PCI手术,90.1%的患者接受了初级PCI, 9.9%的患者接受了选择性PCI。除1例患者外,几乎所有患者(98.9%)均接受了药物洗脱支架置入术。与历史对照组相比,血管紧张素转换酶(ACE)抑制剂/血管紧张素受体阻滞剂(ACEIs/ARBs)的使用率(94.5% vs. 76.5%;P < 0.001),受体阻滞剂(93.4% vs. 81.4%;P = 0.013),高强度他汀类药物(90.1% vs. 33.3%;p < 0.001)在pci术后6个月的临床组中较高。临床药师最常见的3种干预措施是建议开始新的治疗方案(52.4%)、建议调整给药方案(36.7%)和建议改变治疗方案(10.9%)。结论pci术后临床二级预防药物使用率高于历史对照组。
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