Grid-based analysis of three-dimensional choroidal Sattler's and Haller's layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY BMC Ophthalmology Pub Date : 2024-12-18 DOI:10.1186/s12886-024-03784-0

Yuyao Qu, Jixian Ma, Rong Di, Yue Bian, Yuchen Li, Hanze Zhang, Yazhou Qin, Qiuping Liu, Jianqin Lei, Jingming Li

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Abstract

Background: This study was to evaluate the features of choroidal Sattler's and Haller's layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiography (ultra-widefield SS-OCTA).

Methods: 24mm × 20mm fovea centered rectangular SS-OCTA scans were acquired. They were divided into 9 identical grids, with each equal size of 8 mm × 6.7 mm. OCTA artifacts were evaluated. Three-dimensional choroidal vascularity volume index (CVI) and choroidal vascular volume per unit area (CVV/a or CVV) of CSHL were calculated. The correlations of CVI and CVV with age, AL, and BMI were analyzed.

Results: Artifacts account for 19.30%, 18.60%, 30.23% of three inferior grids, respectively. CVI and CVV of left eyes were 30.82 ± 0.28% and 76.76 ± 2.19μm, respectively. Similary, CVI and CVV of right eyes were 31.16 ± 0.34% and 80.49 ± 3.10μm. Strong relationships of CVI (0.877, P = 0.000) and CVV (0.866, P = 0.000) were found between the two eyes in the same individual. The covariance of CVI is lower than that of CVV. Higher CVI was associated with younger age and shorter AL. Neither CVI nor CVV has association with BMI.

Conclusions: CVI can be a more stable parameter for describing choroidal medium and large-sized vessels compared to CVV. Aging and longer AL were associated with attenuated CSHL's vascularity. Taken together, these findings may provide helpful and referential CSHL vascular parameters for retinal specialists to reveal risk factors of choroidal diseases.

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基于网格的超宽视场扫描源光学相干断层扫描血管造影成人三维脉络膜Sattler’s和Haller’s层血管体积指数及其与年龄和轴长关系分析

背景：本研究采用超宽视场扫描源光学相干断层扫描血管造影（超宽视场SS-OCTA）评价成人脉络膜Sattler’s and Haller’s layer （CSHL）血管特征，探讨其与年龄、轴向长度（AL）、体重指数（BMI）等因素的关系。方法：取24mm × 20mm中央凹中心矩形SS-OCTA扫描。它们被分成9个相同的网格，每个网格的大小为8毫米× 6.7毫米。评估OCTA工件。计算CSHL的三维脉络膜血管体积指数（CVI）和单位面积脉络膜血管体积（CVV/a或CVV）。分析CVI、CVV与年龄、AL、BMI的相关性。结果：三个劣格的伪影分别占19.30%、18.60%、30.23%。左眼CVI和CVV分别为30.82±0.28%和76.76±2.19μm。右眼CVI和CVV分别为31.16±0.34%和80.49±3.10μm。同一个体的双眼CVI （0.877, P = 0.000）和CVV （0.866, P = 0.000）之间存在较强的相关性。CVI的协方差小于CVV。较高的CVI与较年轻的年龄和较短的AL相关。CVI和CVV与BMI无关。结论：与CVV相比，CVI是描述脉络膜中、大血管更稳定的参数。衰老和延长AL与CSHL的血管性减弱有关。综上所述，这些发现可能为视网膜专家揭示脉络膜疾病的危险因素提供有用和参考的CSHL血管参数。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.