Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer's disease: a comprehensive review.

IF 5.3 2区医学 Q2 IMMUNOLOGY Inflammopharmacology Pub Date : 2025-02-01 Epub Date: 2024-12-19 DOI:10.1007/s10787-024-01622-9

Mahmood Jawad, Subasini Uthirapathy, Farag M A Altalbawy, Enwa Felix Oghenemaro, Jasur Rizaev, Madan Lal, Mamdouh Eldesoqui, Naveen Sharma, Atreyi Pramanik, Ahmed Khudhair Al-Hamairy

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Abstract

Alzheimer's disease is a devastating neurodegenerative disorder that affects millions of people worldwide. One of the key pathological features of Alzheimer's disease is oxidative stress, which is characterized by an imbalance between the production of reactive oxygen species and the body's ability to neutralize them with antioxidants. In recent years, there has been growing interest in the potential role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer's disease. This review paper aims to provide a comprehensive overview of the current research on antioxidant supplementation in Alzheimer's disease and its effects on oxidative stress markers. The paper will examine the underlying mechanisms of oxidative stress in Alzheimer's disease, the potential benefits of antioxidant supplementation, and the challenges and limitations of using antioxidants as a therapeutic strategy.

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研究抗氧化剂补充在减轻阿尔茨海默病氧化应激标志物中的作用：一项全面的综述。

阿尔茨海默病是一种毁灭性的神经退行性疾病，影响着全世界数百万人。阿尔茨海默病的关键病理特征之一是氧化应激，其特征是活性氧的产生与身体用抗氧化剂中和它们的能力之间的不平衡。近年来，人们对抗氧化剂补充剂在减轻阿尔茨海默病氧化应激标志物中的潜在作用越来越感兴趣。本文就抗氧化剂在阿尔茨海默病中的作用及其对氧化应激标志物的影响的研究现状进行综述。本文将探讨阿尔茨海默病中氧化应激的潜在机制，抗氧化剂补充的潜在益处，以及使用抗氧化剂作为治疗策略的挑战和局限性。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]