Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI:10.1080/14647273.2024.2441827

N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur

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Abstract

This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.

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预防卵巢过度刺激综合征（OHSS）：英国生育学会政策和实践指南。

本英国生育学会（BFS）政策和实践指南旨在支持临床医生在接受促性腺激素卵巢刺激的患者中预防卵巢过度刺激综合征（OHSS）。对医学数据库进行了系统的文献检索。指南制定小组（GDG）确定了卵巢刺激前和刺激期间OHSS的危险因素。评价不同的治疗前措施和不同的卵巢刺激方案与OHSS的关系。评估治疗期间的最佳监测。目前的证据在卵巢刺激期间和之后的预防策略和可用的辅助预防药物进行了检查。基于此，GDG为临床实践制定了基于证据的分级建议。考虑到辅助生殖技术对患者和医疗保健提供者的有效性、成本和实际问题，对证据进行了综合评估。早期识别和应用本指南中确定的预防措施可以减少OHSS的发生率或降低其严重程度。最后，对今后OHSS预防研究提出建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.