Fengling Li, Yani Wei, Li Li, Fei Chen, Chunjuan Bao, Hong Bu, Zhang Zhang
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引用次数: 0
Abstract
Background and objectives: The tumor-associated stroma is an essential compartment in breast cancer, and collagen fiber organization in the stroma has been reported to be correlated with prognosis. In this study, we sought to evaluate collagen fiber characteristics in relation to pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer patients.
Methods: A total of 388 breast cancer patients receiving NAC were enrolled. The stroma type was manually assessed on pretreatment hematoxylin and eosin (HE)-stained slides, and the collagen fiber features were quantified by a computer tool. The relationship between syndecan-1 expression and collagen fibers and its correlation with treatment efficacy were detected by immunohistochemistry.
Results: The pCR rate of patients with collagen-dominant stroma was lower than that of patients with lymphocyte-dominant stroma (19.6% vs. 40.0%, p = 0.001). Patients who achieved pCR had straighter and less dense fibers in pretreatment biopsied tissue than non-pCR patients (p = 0.031, p = 0.044). Additionally, the pCR group had greater syndecans-1 expression on the tumor epithelium than the non-pCR group (p < 0.001), while there was no statistically significant difference in the stroma (p = 0.333). Collagen fiber density was the only factor associated with pCR after correction for other clinicopathological variables in triple-negative breast cancer (TNBC) patients (OR 0.466, 95% CI 0.227-0.956, p = 0.037); patients with lower fiber density had a greater pCR rate (37.5% vs. 12.5%, p = 0.021).
Conclusions: Collagen fiber density was associated with pCR in patients with breast cancer, and it could be a potential candidate for discriminating between responders and nonresponders for TNBC patients receiving NAC.
背景与目的:肿瘤相关间质是乳腺癌的重要间室,基质中胶原纤维组织与预后相关。在这项研究中,我们试图评估乳腺癌患者新辅助化疗(NAC)后胶原纤维特征与病理完全缓解(pCR)的关系。方法:共纳入388例接受NAC治疗的乳腺癌患者。在前处理的苏木精和伊红(HE)染色玻片上手工评估基质类型,并通过计算机工具定量胶原纤维特征。免疫组化检测syndecan-1表达与胶原纤维的关系及与治疗效果的相关性。结果:胶原显性基质患者的pCR率低于淋巴细胞显性基质患者(19.6% vs. 40.0%, p = 0.001)。获得pCR的患者比未获得pCR的患者在预处理活检组织中纤维更直、密度更低(p = 0.031, p = 0.044)。此外,pCR组在肿瘤上皮上的syndecans-1表达高于非pCR组(p)。结论:乳腺癌患者的胶原纤维密度与pCR相关,它可能是鉴别TNBC患者NAC应答和无应答的潜在候选物。
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.