Zachary Barrett-O'Keefe, Chera L Maarouf, Jessica A Narum, Timothy J Fuller, James M Welper, William R Miranda, C Charles Jain, Heidi M Connolly, Luke J Burchill, Alexander C Egbe
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引用次数: 0
Abstract
Exercise intolerance is a hallmark symptom in adults with tetralogy of Fallot (TOF). This may be attributed to impairments in right ventricular (RV) function, augmentation in RV load, and their effect on left ventricular (LV) hemodynamics. To elucidate these mechanisms, we examined oxygen uptake (VO2) and cardiac hemodynamics in TOF and healthy controls at rest and during exercise. At peak exercise, VO2 was lower in TOF. This was partially attributed to lower heart rate in conjunction with a blunted exercise-induced change in LV stroke volume from rest to compensate for the chronotropic incompetence. Additionally, at peak exercise, pulmonary-RV was higher in TOF. Additionally, at peak exercise, in TOF, pulmonary-RV coupling negatively correlated with VO2 , changes in LV end-diastolic volume, and changes in LV SV from rest. These findings reveal the reliance of LV hemodynamics on the interplay between RV systolic load and function during exercise in TOF.
期刊介绍：
The Journal of the American Society of Echocardiography(JASE) brings physicians and sonographers peer-reviewed original investigations and state-of-the-art review articles that cover conventional clinical applications of cardiovascular ultrasound, as well as newer techniques with emerging clinical applications. These include three-dimensional echocardiography, strain and strain rate methods for evaluating cardiac mechanics and interventional applications.
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