Effects of valproic acid, levetiracetam, carbamazepine, and oxcarbazepine on thyroid function tests in children.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI:10.1590/1806-9282.20241177

Olcay Güngör, Beste Kipçak Yüzbaşı, Bayram Özhan, Onur Orhan, Rümeysa Şevik, Gülay Güngör

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Abstract

Objective: The aim of the study was to evaluate the effects of commonly used medications for epilepsy on thyroid function tests in children.

Methods: Epileptic children treated with valproic acid, levetiracetam, carbamazepine, and oxcarbazepine were retrospectively examined along with a healthy control group. Levels of free thyroxine 4 and thyroid-stimulating hormone were compared.

Results: In patients receiving valproic acid monotherapy, thyroid-stimulating hormone levels increased compared to both the control group and pre-treatment levels, while free thyroxine 4 levels remained unchanged. In those receiving carbamazepine or oxcarbazepine monotherapy, average free thyroxine 4 levels were found to be lower compared to the control group and pre-treatment levels, with no difference in thyroid-stimulating hormone levels. For patients receiving levetiracetam monotherapy, there was no difference in free thyroxine 4 and thyroid-stimulating hormone levels compared to the control group and pre-treatment levels.

Conclusion: Despite significant changes in thyroid hormone levels with valproic acid, carbamazepine, and oxcarbazepine treatment, no significant clinical findings were observed. Additionally, no effect of levetiracetam on thyroid function tests was detected.

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研究目的研究旨在评估治疗癫痫的常用药物对儿童甲状腺功能检测的影响：方法：对接受丙戊酸、左乙拉西坦、卡马西平和奥卡西平治疗的癫痫患儿以及健康对照组进行回顾性研究。比较了游离甲状腺素4和促甲状腺激素的水平：结果：在接受丙戊酸单一疗法的患者中，促甲状腺激素水平与对照组和治疗前水平相比均有所上升，而游离甲状腺素 4 的水平则保持不变。在接受卡马西平或奥卡西平单一疗法的患者中，发现游离甲状腺素4的平均水平低于对照组和治疗前水平，而促甲状腺激素水平没有差异。接受左乙拉西坦单药治疗的患者，游离甲状腺素4和促甲状腺激素水平与对照组和治疗前水平相比没有差异：结论：尽管丙戊酸、卡马西平和奥卡西平治疗后甲状腺激素水平会发生明显变化，但并未观察到明显的临床结果。此外，也未发现左乙拉西坦对甲状腺功能检测有任何影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista da Associacao Medica Brasileira (1992)

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