Biological brain age and resilience in cognitively unimpaired 70-year-old individuals

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-12-20 DOI:10.1002/alz.14435

Anna Marseglia, Caroline Dartora, Jessica Samuelsson, Konstantinos Poulakis, Rosaleena Mohanty, Sara Shams, Olof Lindberg, Lina Rydén, Therese Rydberg Sterner, Johan Skoog, Anna Zettergren, Silke Kern, Ingmar Skoog, Eric Westman

{"title":"Biological brain age and resilience in cognitively unimpaired 70-year-old individuals","authors":"Anna Marseglia, Caroline Dartora, Jessica Samuelsson, Konstantinos Poulakis, Rosaleena Mohanty, Sara Shams, Olof Lindberg, Lina Rydén, Therese Rydberg Sterner, Johan Skoog, Anna Zettergren, Silke Kern, Ingmar Skoog, Eric Westman","doi":"10.1002/alz.14435","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>This study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger-looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white-matter alterations, inflammation, high glucose, poorer vascular-related cognitive domains. Sex-specific associations were identified.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Vascular-related lifestyles and health shape brain appearance. Inflammation and insulin-related processes may be keys to understanding vascular cognitive disorders.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>BAG, reflecting deviations from CA, can indicate resilience.</li>\n \n <li>Diabetes, stroke, and low physical activity link to “older” brains (greater BAG).</li>\n \n <li>Physical activity yielded to “younger” brains in septuagenarians with obesity.</li>\n \n <li>High cerebrovascular burden, inflammation, and glucose associate with “older” brains.</li>\n \n <li>Sex differences were detected in all BAG-associated factors.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 2","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14435","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14435","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

This study investigated the associations of brain age gap (BAG)—a biological marker of brain resilience—with life exposures, neuroimaging measures, biological processes, and cognitive function.

METHODS

We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.

RESULTS

Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger-looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white-matter alterations, inflammation, high glucose, poorer vascular-related cognitive domains. Sex-specific associations were identified.

DISCUSSION

Vascular-related lifestyles and health shape brain appearance. Inflammation and insulin-related processes may be keys to understanding vascular cognitive disorders.

Highlights

BAG, reflecting deviations from CA, can indicate resilience.
Diabetes, stroke, and low physical activity link to “older” brains (greater BAG).
Physical activity yielded to “younger” brains in septuagenarians with obesity.
High cerebrovascular burden, inflammation, and glucose associate with “older” brains.
Sex differences were detected in all BAG-associated factors.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

70岁认知未受损个体的生物脑年龄和恢复力

本研究调查了脑年龄差距（BAG）——大脑恢复力的生物学标记——与生活暴露、神经成像测量、生物过程和认知功能的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.