T. V. Andreeva, A. V. Efremenko, A. V. Feofanov, A. V. Lyubitelev, A. N. Korovina, V. M. Studitsky, N. V. Maluchenko
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引用次数: 0
Abstract
A plant-derived polyphenol, genistein, has a high level of biological activity, which stimulates the study of its applicability for the prevention and treatment of tumor, cardiovascular and neurodegenerative diseases. Taking into account the ability of genistein to bind to DNA the interaction of genistein with nucleosomes and nucleosome complexes with poly(ADP-ribose) polymerase 1 (PARP1) has been studied in this work. It was found that genistein did not affect the structure of nucleosomal DNA in a wide range of concentrations, while at high concentrations it caused a change in the structure of linker DNA, bringing the DNA helices closer together. In chromatosomes, genistein did not cause dissociation of the linker histone and conformation changes in the linker DNA region. At high concentrations, genistein hindered the formation of nucleosome complexes with PARP1.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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