Front Cover: Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions (ChemMedChem 23/2024)

Abstract

This cover illustrates the encapsulation of amyloid beta (Aβ) peptides within reverse micelles, symbolizing the controlled aggregation of Aβ oligomers within these nano-sized environments. The reverse micelles facilitate a rapid coalesce-and-separate process, where the Aβ peptides inside are brought together to form oligomers. The size of these oligomers is constrained by the physical dimensions of the reverse micelle, offering a unique way to study their aggregation process in a controlled setting. This artwork captures the dynamic interaction and precise regulation of oligomer size within the micelles. More details can be found in article 10.1002/cmdc.202400310 by Jerry Chun Chung Chan and co-workers.